Protective Impact of Curcumin against Paracetamol-Induced Hepatotoxicity in Rats
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Date
2019-01
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Pharmaceutical Research and Allied Sciences
Abstract
The present study was planned to investigate the protective impact of curcumin on hepatotoxicity of paracetamol in malealbino rats. Thirty-five male albino rats were allocated into seven equal groups, each of five rats, 1st group was kept ascontrol, 2nd group orally administered tween 80 (0.5 ml/200 g b. wt) for 15 days, 3rd group received silymarin (200 mg/kgb. wt) orally for 15 days, 4th group received curcumin (200 mg/kg b. wt) orally for 15 days, 5th group orally administeredparacetamol (500 mg/kg b. wt) for the last 5 days, 6th group was given silymarin and paracetamol, 7th group was givencurcumin and paracetamol. The hepatotoxicity of paracetamol in rats displayed a significant reduction in erythrocytic count(RBCs), concentration of hemoglobin (Hb), the values of packed cell volume (PCV) and mean corpuscular hemoglobinconcentration (MCHC) with a critical elevation in mean corpuscular volume (MCV), platelets (Plts), white blood cells(WBCs) and neutrophils count. Silymarin or curcumin administration with paracetamol in rats produced a significantincrease in RBCs, Hb, PCV and MCHC with a significant decrease in MCV, Plts, WBCs and neutrophils count. Liverenzymes (ALT and AST) and total bilirubin were significantly increased post administration of paracetamol whereasadministration of silymarin or curcumin with paracetamol significantly decreased the activities of liver enzymes and totalbilirubin. Paracetamol administration in rats produced a significant increase in tumor-necrosis factor-alpha (TNF-α) leveland lactate-dehydrogenase enzyme (LDH) activity. Silymarin or curcumin administration with paracetamol displayed acritical decrease in TNF-α and LDH activity. Paracetamol elicited a critical decrease in catalase (CAT), superoxidedismutase (SOD) and glutathione peroxidase (GPX) activities with a critical elevation in malondialdehyde (MDA)concentration. Silymarin or curcumin administration with paracetamol evoked a critical elevation in CAT, SOD and GPXactivities with a significant decrease in MDA concentration. Histopathological examination of paracetamol treated ratsdisplayed alterations in liver histoarchitecture with degenerative and necrotic changes in hepatic cells but restored to nearlynormal picture by pretreatment with silymarin and curcumin. Curcumin has a hepatoprotective effect on paracetamolinduced-hepatotoxicity in rats.
Description
Keywords
Silymarin, Curcumin, Paracetamol, Hepatotoxicity, Rats
Citation
Fadil Hosny Abd El, Nagah Edress, Nadia Khorshid, Noha Amin. Protective Impact of Curcumin against Paracetamol-Induced Hepatotoxicity in Rats. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 84-94