Role of serum cardiac Troponin-I for risk stratification in first attack in acute myocardial infarction.
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Date
2009-06
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Abstract
Introduction: Cardiac troponin-I (cTnI) is known to have the highest specificity and analytic
sensitivity for detection of myocardial injury; it is used both as diagnostic and prognostic marker. This
study was aimed to confirm this idea. Subjects & methods: This prospective observational study
included 60 patients of 40 to 65 years age range diagnosed as acute myocardial infarction. The mean
ages were 50±8 years and 53±8 years in Q –wave AMI and non Q-wave AMI respectively. Male and
female patients included were 86.7% and 13.3%; BMI was 25.3±1.5. Results: Study showed
troponin-I 7.53±0.086 ng/ml in Q wave and in non Q-wave AMI was 6.38±0.64 ng/ml after 24 hours
of attack of AMI without any significant difference between two groups (P>0.05). The mean
troponin-I within 9 hours of attack, were 1.60±0.80 ng/ml and 2.7±1.4 ng/ml in stable and unstable
group respectively and the difference found statistically significant (P<0.05). The mean troponin-I
between 9-24 hours of attack were 2.90±1.20 ng/ml and 4.90±3.20 ng/ml in stable and unstable group
respectively and the difference found statistically significant (P<0.01). The mean troponin-I in
unstable group after 24 hours was 9.20±4.30 ng/ml which was more than between 9-24 hours and the
difference was significant (P>0.001). In clinicopathological outcome evaluation 37 patients had
troponin-I level >1.5 ng/ml in which 29 patients developed unstability and 8 patients were stable.
Conclusion: Serum cTnI is better and more characteristic biomarker for risk prediction and prognosis
evaluation in AMI patients.
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Keywords
Cardiac Troponin-I, acute myocardial infarction, risk stratification
Citation
Sahabuddin Joarder M, Jafarullah M, Moinuddin A. Role of serum cardiac Troponin-I for risk stratification in first attack in acute myocardial infarction. Bangladesh Journal of Medical Science. 2009; 8(3): 57-63.