Antihypertensive Efficacy of Carvedilol and Amlodipine in Patients of Mild to Moderate Hypertension – A Comparative Study

Simple item page
dc.contributor.authorVerma, Ujala
dc.contributor.authorBano, Gulshan
dc.contributor.authorLal, Mohan
dc.contributor.authorKapoor, B
dc.contributor.authorSharma, P
dc.contributor.authorSharma, Rashmi
dc.date.accessioned2016-01-29T06:27:04Z
dc.date.available2016-01-29T06:27:04Z
dc.date.issued2004-10
dc.description.abstractIn this prospective randomized parallel study, the antihypertensive effect of oral carvedilol and amlodipine was evaluated on systolic blood pressure (SBP) and diastolic blood pressure(DBP) in patients of mild to moderate hypertension over a period of 12 weeks. Eighty two patients who fulfilled the inclusion criteria were randomized to receive amlodipine (n=42) 5-10mg/day and carvedilol (n=40) 25-50mg/day. Blood pressure was recorded in the sitting and standing position during follow up visits at 2,4,8 and 12 weeks using mercury sphygmomanometer. Dosage adjustments if needed were made at 4 and 8 weeks of study. Both carvedilol and amlodipine produced a statistically significant (P<0.001) and dose related fall in SBP and DBP , which became evident at two weeks of initiation of therapy and continued till 12 weeks. On comparative analysis of the effect of carvedilol and amlodipine on BP, amlodipine produced a greater fall in sitting and standing SBP at all study intervals as compared to carvedilol, with statistically significant fall at 8 and 12 weeks (P<0.01). However, the fall in sitting and standing DBP was statistically comparable with both the drugs. The findings of the present study indicate that carvedilol has become an alternative treatment for mild to moderate hypertension.en_US
dc.identifier.citationVerma Ujala, Bano Gulshan, Lal Mohan, Kapoor B, Sharma P, Sharma Rashmi. Antihypertensive Efficacy of Carvedilol and Amlodipine in Patients of Mild to Moderate Hypertension – A Comparative Study. JK Science Journal of Medical Education and Research. 2004 Oct-Dec;6(4): 193-196en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/171171
dc.language.isoenen_US
dc.source.urihttps://www.jkscience.org/archive/volume64/antihypertension.pdfen_US
dc.subjectHypertensionen_US
dc.subjectAmlodipineen_US
dc.subjectCarvedilolen_US
dc.titleAntihypertensive Efficacy of Carvedilol and Amlodipine in Patients of Mild to Moderate Hypertension – A Comparative Studyen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jksjmer2004v6n4p193.pdf
Size:
84.55 KB
Format:
Adobe Portable Document Format
Description:
Original Articles
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
JK Science Journal of Medical Education and Research