Antihypertensive Efficacy of Carvedilol and Amlodipine in Patients of Mild to Moderate Hypertension – A Comparative Study
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Date
2004-10
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Abstract
In this prospective randomized parallel study, the antihypertensive effect of oral carvedilol and
amlodipine was evaluated on systolic blood pressure (SBP) and diastolic blood pressure(DBP) in
patients of mild to moderate hypertension over a period of 12 weeks. Eighty two patients who
fulfilled the inclusion criteria were randomized to receive amlodipine (n=42) 5-10mg/day and carvedilol
(n=40) 25-50mg/day. Blood pressure was recorded in the sitting and standing position during follow
up visits at 2,4,8 and 12 weeks using mercury sphygmomanometer. Dosage adjustments if needed
were made at 4 and 8 weeks of study. Both carvedilol and amlodipine produced a statistically
significant (P<0.001) and dose related fall in SBP and DBP , which became evident at two weeks of
initiation of therapy and continued till 12 weeks. On comparative analysis of the effect of carvedilol and
amlodipine on BP, amlodipine produced a greater fall in sitting and standing SBP at all study intervals as
compared to carvedilol, with statistically significant fall at 8 and 12 weeks (P<0.01). However, the fall in
sitting and standing DBP was statistically comparable with both the drugs. The findings of the present
study indicate that carvedilol has become an alternative treatment for mild to moderate hypertension.
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Keywords
Hypertension, Amlodipine, Carvedilol
Citation
Verma Ujala, Bano Gulshan, Lal Mohan, Kapoor B, Sharma P, Sharma Rashmi. Antihypertensive Efficacy of Carvedilol and Amlodipine in Patients of Mild to Moderate Hypertension – A Comparative Study. JK Science Journal of Medical Education and Research. 2004 Oct-Dec;6(4): 193-196