Acid Sensing Ion Channels (asics): Potential Targets For The Discovery Of Novel Therapeutics In Disease Management

Simple item page
dc.contributor.authorRoy, Debendra Nathen_US
dc.date.accessioned2020-05-05T07:06:08Z
dc.date.available2020-05-05T07:06:08Z
dc.date.issued2018-01
dc.description.abstractAcid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurological (pa hological pain, expression of fear, anxie y, depression, and neurodegeneration after ischemic s roke e c) and non-neurological (brain umor, cardiovascular mechanosensation, hypoxia induced hyper ension, glaucoma, e c.) disor-ders are implica ed by various ASICs sub ypes. Due o heir known and po ential roles in many disease pa hologies, i is very au hentic o explore he impor ance of new and selective small molecule inhibi ors and even activa ors of ASICs as a research ool in clinical uses for reating hese diseases pa hogenesis. This review is aimed o find ou he herapeutic po entialities of ASICs arge ed novel drugs in con ex of heir pa hophysiological role in human body. Fluorescen dyes and optical sensors as a means of fas and efficien screening approaches would cer ainly be used o improve he discovery echnology of ASICs modula ed drugs.en_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacy, Faculty of Biological Science and Technology, Jessore University of Science and Technology, Jessore - 7408, Bangladeshen_US
dc.identifier.citationRoy Debendra Nath. Acid Sensing Ion Channels (asics): Potential Targets For The Discovery Of Novel Therapeutics In Disease Management. International Journal of Clinical and Biomedical Research. 2018 Jan; 4(1): 62-68en_US
dc.identifier.issn2395-0471
dc.identifier.issn2521-0394
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200786
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber1en_US
dc.relation.volume4en_US
dc.source.urihttps://www.doi.org/10.5455/ijcbr.2018.41.13en_US
dc.subjectAciden_US
dc.subjection channelen_US
dc.subjectdiscoveryen_US
dc.subjectpharmacologicalen_US
dc.subjectdisease.en_US
dc.titleAcid Sensing Ion Channels (asics): Potential Targets For The Discovery Of Novel Therapeutics In Disease Managementen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijcbr2018v4n1p62.pdf
Size:
329.08 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Clinical and Biomedical Research (IJCBR)