Acid Sensing Ion Channels (asics): Potential Targets For The Discovery Of Novel Therapeutics In Disease Management
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Date
2018-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Sumathi Publications
Abstract
Acid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurological (pa hological pain, expression of fear, anxie y, depression, and neurodegeneration after ischemic s roke e c) and non-neurological (brain umor, cardiovascular mechanosensation, hypoxia induced hyper ension, glaucoma, e c.) disor-ders are implica ed by various ASICs sub ypes. Due o heir known and po ential roles in many disease pa hologies, i is very au hentic o explore he impor ance of new and selective small molecule inhibi ors and even activa ors of ASICs as a research ool in clinical uses for reating hese diseases pa hogenesis. This review is aimed o find ou he herapeutic po entialities of ASICs arge ed novel drugs in con ex of heir pa hophysiological role in human body. Fluorescen dyes and optical sensors as a means of fas and efficien screening approaches would cer ainly be used o improve he discovery echnology of ASICs modula ed drugs.
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Keywords
Acid, ion channel, discovery, pharmacological, disease.
Citation
Roy Debendra Nath. Acid Sensing Ion Channels (asics): Potential Targets For The Discovery Of Novel Therapeutics In Disease Management. International Journal of Clinical and Biomedical Research. 2018 Jan; 4(1): 62-68