Anti-inflammtory activity of Ocimum Sanctum (linn) in formalin induced acute models of albino rats.
| dc.contributor.author | Mirje, Mrutyunjay M | |
| dc.contributor.author | Kumbar, Shivaprasad | |
| dc.contributor.author | Moharir, Gurudatta | |
| dc.date.accessioned | 2016-11-19T07:00:33Z | |
| dc.date.available | 2016-11-19T07:00:33Z | |
| dc.date.issued | 2015-01 | |
| dc.description.abstract | The inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, physical injuries). Many nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone, indomethacin etc. are in clinical use but all these are not completely devoid of adverse effects2. In this study, the anti-inflammatory activity of 0. sanctum alone and in combination with indomethacin was studied using formalin-induced rat paw edema. Aqueous extract of O. sanctum (200mg/kg, 300mg/kg or 400mg/kg) was administered alone and in combination with indomethacin (25mg/kg) to separate group of rats and paw volume was measured by plethysmometer and compared with control group. All the test groups showed significant (P<0.05) anti-inflammatory effect in formalin-induced rat paw edema. The reduction of edema by 0. sanctum was better than that of the standard anti-inflammatory drug, indomethacin and on co-administration marginally improved the anti-inflammatory profile of indomethacin. O.sanctum possesses significant anti-inflammatory activity probably due to inhibition of both cyclooxygenase and lipooxygenase pathways of arachidonic acid metabolism (dual inhibitory property). | en_US |
| dc.identifier.citation | Mrutyunjay M Mirje, Shivaprasad Kumbar, Gurudatta Moharir. Anti-inflammtory activity of Ocimum Sanctum (linn) in formalin induced acute models of albino rats. International Journal of Clinical and Biomedical Research. 2015 Jan-Mar; 1(1): 1-4 | en_US |
| dc.identifier.issn | 2395 - 0471 | |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/178562 | |
| dc.language.iso | en | en_US |
| dc.subject | Nonsteroidal anti- inflammatory drugs (NSAIDs) | en_US |
| dc.subject | Indomethacin | en_US |
| dc.subject | Plethysmometer. | en_US |
| dc.title | Anti-inflammtory activity of Ocimum Sanctum (linn) in formalin induced acute models of albino rats. | en_US |
| dc.type | Article | en_US |