Anti-inflammtory activity of Ocimum Sanctum (linn) in formalin induced acute models of albino rats.
Date
2015-01
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Abstract
The inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, physical injuries). Many nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone, indomethacin etc. are in clinical use but all these are not completely devoid of adverse effects2. In this study, the anti-inflammatory activity of 0. sanctum alone and in combination with indomethacin was studied using formalin-induced rat paw edema. Aqueous extract of O. sanctum (200mg/kg, 300mg/kg or 400mg/kg) was administered alone and in combination with indomethacin (25mg/kg) to separate group of rats and paw volume was measured by plethysmometer and compared with control group. All the test groups showed significant (P<0.05) anti-inflammatory effect in formalin-induced rat paw edema. The reduction of edema by 0. sanctum was better than that of the standard anti-inflammatory drug, indomethacin and on co-administration marginally improved the anti-inflammatory profile of indomethacin. O.sanctum possesses significant anti-inflammatory activity probably due to inhibition of both cyclooxygenase and lipooxygenase pathways of arachidonic acid metabolism (dual inhibitory property).
Description
Keywords
Nonsteroidal anti- inflammatory drugs (NSAIDs), Indomethacin, Plethysmometer.
Citation
Mrutyunjay M Mirje, Shivaprasad Kumbar, Gurudatta Moharir. Anti-inflammtory activity of Ocimum Sanctum (linn) in formalin induced acute models of albino rats. International Journal of Clinical and Biomedical Research. 2015 Jan-Mar; 1(1): 1-4