Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent.

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dc.contributor.authorSen, Sen_US
dc.contributor.authorHabibuddin, Men_US
dc.contributor.authorPal, S Pen_US
dc.date.accessioned2009-05-28T16:17:06Z
dc.date.available2009-05-28T16:17:06Z
dc.date.issued1994-10-01en_US
dc.description.abstractA new derivative of gamma-aminobutyric acid (GABA) was synthesized. The compound, N-octanoyl GABA (O-GABA), exhibited positive analgesic response in four different models in mice--tail immersion, hot plate, tail clip and acetic acid induced writhing. The antinociceptive activity was significantly blocked by picrotoxin but not by bicuculline or 3-mercaptopropionic acid. Naloxone failed to reverse the antinociceptive response of O-GABA but a synergistic action was observed with pethidine. Pretreatment with atropine significantly reduced the antinociceptive action of O-GABA. Biochemical tests revealed that O-GABA significantly increased brain GABA levels.en_US
dc.description.affiliationDepartment of Pharmaceutical Technology, Jadaypur University, Calcutta, India.en_US
dc.identifier.citationSen S, Habibuddin M, Pal SP. Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent. Indian Journal of Experimental Biology. 1994 Oct; 32(10): 718-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63040
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnalgesics --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshGABA Agonists --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshgamma-Aminobutyric Acid --analogs & derivativesen_US
dc.titleAntinociceptive action of N-octanoyl GABA--a new GABA mimetic agent.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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