Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent.

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Date
1994-10-01
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Abstract
A new derivative of gamma-aminobutyric acid (GABA) was synthesized. The compound, N-octanoyl GABA (O-GABA), exhibited positive analgesic response in four different models in mice--tail immersion, hot plate, tail clip and acetic acid induced writhing. The antinociceptive activity was significantly blocked by picrotoxin but not by bicuculline or 3-mercaptopropionic acid. Naloxone failed to reverse the antinociceptive response of O-GABA but a synergistic action was observed with pethidine. Pretreatment with atropine significantly reduced the antinociceptive action of O-GABA. Biochemical tests revealed that O-GABA significantly increased brain GABA levels.
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Sen S, Habibuddin M, Pal SP. Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent. Indian Journal of Experimental Biology. 1994 Oct; 32(10): 718-23
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https://imsear.searo.who.int/handle/123456789/63040
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Indian Journal of Experimental Biology