Clustered regularly interspaced short palindromic repeats cas systems: a comprehensive review.
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Date
2015-07
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Abstract
The clustered regularly interspaced short palindromic repeats (CRISPR) system was
recently identified as a bacterial defense mechanism against phages and plasmids. The
CRISPR system is composed of DNA arrays containing short sequences identical to
those present in phages and plasmids. These short DNAs are transcribed and processed
by CRISPR associated proteins that also guide other CRISPR proteins to target the
invading DNA. Only a few of the CRISPR components have been characterized
to date, and their mechanism of action is still largely unknown. Phage defense
mechanisms probably have co-evolved against the CRISPR system, but none has yet
been found. We propose to identify phage genes that counteract the CRISPR system.
Description
Keywords
Clustered regularly interspaced short palindromic repeats system Plasmid, DNA, Short sequences
Citation
Mahmud Shahin, Ahmed Jahir, Aziz Md Abdul, Hasan Mirza Rokibu, Shaon Shoaib Mahmud, Bhuiyan Md Naieem Al-Hasan, Rahman Md Farzanoor, Rakib Hasibul Haque, Islam Md Shariful. Clustered regularly interspaced short palindromic repeats cas systems: a comprehensive review. International Journal of Basic & Clinical Pharmacology. 2015 Jul-Aug; 4(4): 613-622.