Derris scandens benth extract radiosensitizes HT-29 colon cancer cells.
| dc.contributor.author | Hematulin, Arunee | |
| dc.contributor.author | Ingkaninan, Kornkanok | |
| dc.contributor.author | Limpeanchob, Nanteetip | |
| dc.contributor.author | Sagan, Daniel | |
| dc.date.accessioned | 2012-01-16T08:21:41Z | |
| dc.date.available | 2012-01-16T08:21:41Z | |
| dc.date.issued | 2011-05 | |
| dc.description.abstract | Objective: To evaluate the radiosensitizing potential of Derris scandens extract in a human colon cancer cell model. Methods: The radiosensitizing effect of D., scandens extract on human colon cancer cells (HT-29) and non-cancerous human retinal epithelial cells (RPE) was determined by cell survival and micronuclei analysis after irradiation. Cell cycle distribution was analyzed by a flow cytometer. Results: D. scandens extract powerfully increases the radiosensitivity of HT-29 cells, but is less toxic and does not affect the radiosensitivity of RPE cells. Furthermore, the extract was found to reduce radiation-induced G2/M phase arrest in HT-29 cells, but not in RPE cells. Conclusion: D., scandens extract may have potential as a radiosensitizer for cancer treatment. | en_US |
| dc.identifier.citation | Hematulin Arunee, Ingkaninan Kornkanok, Limpeanchob Nanteetip, Sagan Daniel. Derris scandens benth extract radiosensitizes HT-29 colon cancer cells. Siriraj Medical Journal, 2011 May; 63(3): 85-88. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/136479 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.sirirajmedj.com/content_download.php?content_id=2592 | en_US |
| dc.subject | Radiosensitizer | en_US |
| dc.subject | Derris scandens Benth | en_US |
| dc.subject | radiotherapy | en_US |
| dc.subject | medicinal plant | en_US |
| dc.subject | cancer | en_US |
| dc.title | Derris scandens benth extract radiosensitizes HT-29 colon cancer cells. | en_US |
| dc.type | Article | en_US |