Derris scandens benth extract radiosensitizes HT-29 colon cancer cells.
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Date
2011-05
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Abstract
Objective: To evaluate the radiosensitizing potential of Derris scandens extract in a human colon cancer cell model.
Methods: The radiosensitizing effect of D., scandens extract on human colon cancer cells (HT-29) and non-cancerous human retinal epithelial cells (RPE) was determined by cell survival and micronuclei analysis after irradiation. Cell cycle distribution was analyzed by a flow cytometer.
Results: D. scandens extract powerfully increases the radiosensitivity of HT-29 cells, but is less toxic and does not affect the radiosensitivity of RPE cells. Furthermore, the extract was found to reduce radiation-induced G2/M phase arrest in HT-29 cells, but not in RPE cells.
Conclusion: D., scandens extract may have potential as a radiosensitizer for cancer treatment.
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Keywords
Radiosensitizer, Derris scandens Benth, radiotherapy, medicinal plant, cancer
Citation
Hematulin Arunee, Ingkaninan Kornkanok, Limpeanchob Nanteetip, Sagan Daniel. Derris scandens benth extract radiosensitizes HT-29 colon cancer cells. Siriraj Medical Journal, 2011 May; 63(3): 85-88.