Depleted immunoglobulin heavy chain binding protein (BiP) expands the endoplasmic reticulum and the golgi apparatus in dengue virus-infected cells.

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dc.contributor.authorWongwiwat, Wiyada
dc.contributor.authorNiyomchan, Apichaya
dc.contributor.authorYenchitsomaus, Pa-thai
dc.contributor.authorSricharoenvej, Sirinush
dc.contributor.authorLimjindaporn, Thawornchai
dc.date.accessioned2012-05-23T09:17:45Z
dc.date.available2012-05-23T09:17:45Z
dc.date.issued2012-01
dc.description.abstractObjective: To test whether depleted expression of immunoglobulin heavy chain binding protein (BiP), which is an endoplasmic reticulum (ER) chaperone, in dengue virus (DENV)-infected cells, affected integrities of the ER and the Golgi apparatus of the host cells. Methods: Either siRNA against BiP- or control siRNA-transfected cells was infected with DENV and subjected to electron microscopic evaluation. Results: Depleted expression of BiP affected integrities of the ER and the Golgi apparatus in DENV-infected cells. Conclusion: Integrities of the ER and the Golgi apparatus maintained by BiP in the host cells is necessary for DENV production.en_US
dc.identifier.citationWongwiwat Wiyada, Niyomchan Apichaya, Yenchitsomaus Pa-thai, Sricharoenvej Sirinush, Limjindaporn Thawornchai. Depleted immunoglobulin heavy chain binding protein (BiP) expands the endoplasmic reticulum and the golgi apparatus in dengue virus-infected cells. Siriraj Medical Journal, 2012 Jan; 64(suppl): 91-92.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138593
dc.language.isoenen_US
dc.source.urihttps://www.sirirajmedj.com/content_download.php?content_id=2655en_US
dc.subjectDengue virusen_US
dc.subjectBiPen_US
dc.subjectEndoplasmic reticulumen_US
dc.subjectGolgi apparatusen_US
dc.subjectRNA interferenceen_US
dc.subjectElectron microscopyen_US
dc.titleDepleted immunoglobulin heavy chain binding protein (BiP) expands the endoplasmic reticulum and the golgi apparatus in dengue virus-infected cells.en_US
dc.typeArticleen_US
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