Investigation of some anaerobic bacteria in the sputum of cystic fibrosis patients and healthy people in Tehran, Iran.
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Date
2024-09
Journal Title
Journal ISSN
Volume Title
Publisher
Dr. M. V. Ghorpade
Abstract
Background: In Cystic Fibrosis (CF) patients, increased mucus secretion and accumulation due to genetic defect leads to decreased oxygen levels and colonization of anaerobic bacteria. Aim and Objectives: In addition to investigating the difference in the prevalence of anaerobic bacteria in the sputum samples of CF patients and healthy populations, this study evaluated the relationship of demographic factors with anaerobic bacteria and CF disease. Material and Methods: Anaerobic bacteria were investigated in sputum samples of CF patients (50 people) and healthy individuals (18 people) in Tehran, Iran by molecular method in 2021-2022. The prevalence of common anaerobic bacteria in CF patients was investigated by Polymerase Chain Reaction (PCR). Results: The relationship between Bifidobacterium and Prevotella in both of healthy and CF groups, as well as the disease and Bifidobacterium (p = 0.0437) and disease and Prevotella (p = 0.0514), were significant. The results of Spearman's correlation also showed an inverse relationship between age and gender (men) with disease and a direct relationship between antibiotic use and disease. Conclusions: The abundance of potentially beneficial species of Bifidobacterium and Prevotella was lower in CF than in healthy people. The role of anaerobic bacteria in the lungs of CF patients is different according to the bacterial genus and species.
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Keywords
Anaerobic Bacteria, Bifidobacterium, Cystic Fibrosis, Lung infection, Prevotella
Citation
Hamayeli H, Abdi-Ali A, Attaran B, Shafiei M, Modaresi M. . Investigation of some anaerobic bacteria in the sputum of cystic fibrosis patients and healthy people in Tehran, Iran. . Journal of Krishna Institute of Medical Sciences University. 2024 Sep; 13(3): 46-59