Investigation of some anaerobic bacteria in the sputum of cystic fibrosis patients and healthy people in Tehran, Iran.

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dc.contributor.authorHamayeli, Hen_US
dc.contributor.authorAbdi-Ali, Aen_US
dc.contributor.authorAttaran, Ben_US
dc.contributor.authorShafiei, Men_US
dc.contributor.authorModaresi, M.en_US
dc.date.accessioned2025-05-12T10:20:11Z
dc.date.available2025-05-12T10:20:11Z
dc.date.issued2024-09
dc.description.abstractBackground: In Cystic Fibrosis (CF) patients, increased mucus secretion and accumulation due to genetic defect leads to decreased oxygen levels and colonization of anaerobic bacteria. Aim and Objectives: In addition to investigating the difference in the prevalence of anaerobic bacteria in the sputum samples of CF patients and healthy populations, this study evaluated the relationship of demographic factors with anaerobic bacteria and CF disease. Material and Methods: Anaerobic bacteria were investigated in sputum samples of CF patients (50 people) and healthy individuals (18 people) in Tehran, Iran by molecular method in 2021-2022. The prevalence of common anaerobic bacteria in CF patients was investigated by Polymerase Chain Reaction (PCR). Results: The relationship between Bifidobacterium and Prevotella in both of healthy and CF groups, as well as the disease and Bifidobacterium (p = 0.0437) and disease and Prevotella (p = 0.0514), were significant. The results of Spearman's correlation also showed an inverse relationship between age and gender (men) with disease and a direct relationship between antibiotic use and disease. Conclusions: The abundance of potentially beneficial species of Bifidobacterium and Prevotella was lower in CF than in healthy people. The role of anaerobic bacteria in the lungs of CF patients is different according to the bacterial genus and species.en_US
dc.identifier.affiliationsDepartment of Microbiology, Faculty of Biological Sciences, Alzahra University- 1993893973 (Tehran) Iranen_US
dc.identifier.affiliationsDepartment of Microbiology, Faculty of Biological Sciences, Alzahra University- 1993893973 (Tehran) Iranen_US
dc.identifier.affiliationsDepartment of Microbiology, Faculty of Biological Sciences, Alzahra University- 1993893973 (Tehran) Iranen_US
dc.identifier.affiliationsDepartment of Bacteriology, Pasteur Institute of Iran-1316943551 (Tehran) Iranen_US
dc.identifier.affiliationsGrowth andDevelopment Research Center, Tehran University of Medical Sciences-1416753955 (Tehran) Iran; Pediatric Pulmonary Disease and Sleep Medicine Research Center, Pediatric Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences-1416753955 (Tehran) Iranen_US
dc.identifier.citationHamayeli H, Abdi-Ali A, Attaran B, Shafiei M, Modaresi M. . Investigation of some anaerobic bacteria in the sputum of cystic fibrosis patients and healthy people in Tehran, Iran. . Journal of Krishna Institute of Medical Sciences University. 2024 Sep; 13(3): 46-59en_US
dc.identifier.issn2231-4261
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247647
dc.languageenen_US
dc.publisherDr. M. V. Ghorpadeen_US
dc.relation.issuenumber3en_US
dc.relation.volume13en_US
dc.source.urihttps://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%2046-59.pdfen_US
dc.subjectAnaerobic Bacteriaen_US
dc.subjectBifidobacteriumen_US
dc.subjectCystic Fibrosisen_US
dc.subjectLung infectionen_US
dc.subjectPrevotellaen_US
dc.titleInvestigation of some anaerobic bacteria in the sputum of cystic fibrosis patients and healthy people in Tehran, Iran.en_US
dc.typeJournal Articleen_US
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