Saccharomyces boulardii CNCM I-745: An Efficient Yeast Probiotic with Unique Properties

Objective: Probiotics have been associated with improved health and well-being. Both bacterial and yeast probiotics can produce anti-carcinogenic, anti-oxidant, and anti-mutagenic effects that induce protection against various bacterial diseases such as diarrhoea and respiratory tract infections. Among yeasts, Saccharomyces genus is found to be effective in improving human health. Saccharomyces boulardii CNCM I-745 is classified as a probiotic with unique properties such as variability of pH over a wide range, inability to obtain antibiotic resistance genes, and the ability to attain a steady state rapidly, providing it an advantage over bacterial probiotics. It plays a significant role in preventing antibiotic-associated diarrhoea and paediatric acute gastroenteritis as compared to bacterial probiotics. Prophylactic use of S. boulardii CNCM I-745 not only showed a significant reduction in the risk of AAD as compared to controls but also restored the gut microbiota diversity. Saccharomyces boulardii CNCM I-745 was also found to be superior to Lactobacillus rhamnosus GG and four strains of Bacillus clausii in reducing the duration of diarrhoea and hospital stay in Indian children with PAGE. Saccharomyces boulardii CNCM I-745 is also recommended by several international guidelines for the management of acute diarrhoea. It is considered a safe probiotic for the prevention of gastrointestinal disorders and it is suitable for use in both children and adults.

Keywords

Antibiotic-associated diarrhoea, Gastrointestinal disorders, Paediatric acute gastroenteritis, Saccharomyces boulardii CNCM I-745, Yeast Probiotics

Citation

Rai A, Singh A, Baliyan A, Choudhary DS, Choudhary P, Chaudhary R, Nara H, Parakh P, Ravindarnath G, Rakesh CH. Saccharomyces boulardii CNCM I-745: An Efficient Yeast Probiotic with Unique Properties. International Journal of Scientific Study. 2024 Jul; 12(4): 46-54

URI

https://imsear.searo.who.int/handle/123456789/242598

Collections

International Journal of Scientific Study

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