Papillon lefevre A rare syndrome
Loading...
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Educational Society for Excellence
Abstract
Papillon lefevre syndrome (PLS) belongs to a heterogeneous group of skin diseases that are characterized by hyperkeratosis of palms and soles and presence of severe and early onset periodontitis. Genetic studies have shown that mutation in the major gene locus of chromosome 11q14 with the loss of function of cathepsin C (CTSC) gene is responsible for PLS. Loss of CTSC function is responsible for the severe periodontal destruction seen clinically. This report represents classical signs and symptoms of PLS in a 6 year old girl.
Description
Keywords
Aggressive periodontitis, Cathepsin C gene, Papillon lefevre syndrome
Citation
Kumar Abhima, Jan Suhail M, Nazir Rafiya, Behal Roobal. Papillon lefevre A rare syndrome. International Archives of Integrated Medicine. 2017 Apr; 4(4): 79-84