To Evaluate The Usefulness of Cytological Grading of Breast Cancer as a Predictor of Lymph Nodal Metastasis.
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Date
2014-10
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Abstract
In a 5-year retrospective and 1-year prospective study a total of 110 fine-needle aspiration cytology
(FNAC) cases of breast cancer were studied. These were graded according to Robinson's and Mouriquand's
grading methods and relationship between grading and lymph node metastasis; cell dissociation parameter
of Robinson's grading and lymph node metastasis evaluated. Of the 110 cases graded by Robinson's
method, Grade I tumours had lymph node involvement in 3.57% of cases. Grade II and Grade III tumours
had lymph node involvement in 6.52% and 47.22% of cases respectively where as when graded by
Mouriquand's method, Grade I tumours had lymph node involvement in 3.57% of cases. Grade II and
Grade III tumours had lymph node involvement in 7.14% and 42.5% of cases respectively. Although both
grading systems showed significant relationship with lymph node involvement but Robinson's grading was
a much better predictor of lymph node metastasis. Our study showed that greater cell dissociation was
associated with higher incidence of regional lymph node metastasis. A highly significant relationship was
observed between cell dissociation and lymph node involvement (p=0.00000). We conclude that cytological
grading of breast cancers is a strong predictor of lymph nodal metastasis and greater cell dissociation is
associated with higher incidence of regional lymph node metastasis.
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Keywords
Breast Cancer, Metastasis, Lymph Nodes
Citation
Bhardwaj Subhash, Wani Farooq Ahmed, Katoch Pervez Ahmed. To Evaluate The Usefulness of Cytological Grading of Breast Cancer as a Predictor of Lymph Nodal Metastasis. JK Science Journal of Medical Education and Research. 2014 Oct-Dec; 16(4): 167-170.