Histomorphometric Study of the Glomeruli of the Kidney in Bangladeshi Population.
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Date
2014-06
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Abstract
Background: Controversies still prevail on glomerular changes of kidney whether due to normal
aging or its association with diseases. Objective: The aim of the present study was to see the
variation in number and size of the glomeruli of kidney with increasing age in a Bangladeshi
population based on autopsy. Methods: This cross-sectional, descriptive study was done in the
Department of Anatomy, Dhaka Medical College, Dhaka, from July 2008 to June 2009, based on
collection of 140 post mortem human kidneys collected from 70 unclaimed dead bodies from the
morgue. All the samples were divided into three age-groups: 10-19 years, 20-39 years and 40-59
years. Histological slides were prepared by using routine Harris’ Haematoxylin and Eosin (H & E)
stain. The number of glomeruli was measured by point counting technique, while the size (diameter)
was measured by using ocular and stage micrometer. Results: The mean ± SE number of glomeruli
per sq. mm found in the right and left kidney were 8.45±0.52 and 8.67±0.80 in group 10-19 years,
9.90±0.42 and 9.92±0.47 in 20-39 years, and 8.52±0.18 and 8.55±0.16 in 40-59 years respectively.
Besides, the size (mean ± SE diameter) of glomeruli was found in the right and left kidney were
43.96±3.01ìm and 143.92±2.90ìm in group 10-19 years, 153.69±5.18ìm and 153.61±5.24ìm in 20-39
years, and 140.48±0.95ìm and 140.78±0.88ìm in 40-59 years respectively. Conclusion: No difference
was found in number and size of glomeruli between right and left kidney in any group. Similarly, no
difference was also evident among different age groups.
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Keywords
Histomorphometry, glomerulus, kidney function, human kidney
Citation
Johora Fatema, Nurunnabi Abu Sadat Mohammad, Shahriah Sunjida, Ahmed Rukshana, Ara Shamim. Histomorphometric Study of the Glomeruli of the Kidney in Bangladeshi Population. Journal of Bangladesh Society of Physiologists. 2014 June; 9(1): 11-16.