Prophylactic Antiemetic Therapy with Ondansetron, Granisetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under GA.
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Date
2008-04
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Abstract
The aim of the present study was to compare the antiemetic effect of intravenous Granisetron, Ondansetron
& Metoclopramide in a randomized blinded study for prophylaxis of post operative nausea and vomiting
(PONV) in patients undergoing laparoscopic cholecystectomy under general anaesthesia. 60 patients
(ASA I & II) undergoing laparoscopic cholecystectomy under general anaesthesia were randomly allocated
into three equal groups (n=20). Emetic episodes in first 24 hours were recorded and compared in different
study groups. Results were analyzed. Minimal emetic episodes were observed in early post-operative
period (1-12hrs) in patients who had received intravenous granisetron in comparison to ondansetron and
metoclopramide. However, after 12 hours emesis free periods were statistically insignificant between
group A and B while patients in group C had no antiemetic effect.
Description
Keywords
Post Operative Nausea and Vomiting (PONV), Granisetron, Ondensetron, Metoclopramide
Citation
Gupta Vishal, Wakhloo Renu, Mehta Anjali, Gupta Satya Dev. Prophylactic Antiemetic Therapy with Ondansetron, Granisetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under GA. JK Science Journal of Medical Education and Research. 2008 Apr-June;10(2): 74-77