Gamma Linolenic Acid in Dry Eye
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Date
2006-01
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Abstract
In this prospective study to evaluate the role of gamma linolenic acid in the management of dry eye, 100
patients of dry eyes were studied by dividing randomly into two groups of 50 each. In the test group, all the
50 patients were put on medication which consisted of cap gamma linolenic acid - 120 mg once daily dose,
artificial tears solution/ointments 4-6 times daily with a topical mild steroid (loteprednol etabonate 0.5%)
thrice daily. In the control group all the 50 patients were put on artificial tear solution/ointments and topical
mild steroid (loteprednol etabonate 0.5%) thrice daily. All the patients were subjected to slit lamp examination,
schirmer test, and fluorescien stain for tear film break up time (TBUT). In the test group symptomatic
relief was shown by all 50 (100%) patients after one week of treatment. There was not much improvement
in the schirmer test and TBUT results at 1 week. At 1 month follow up the result showed improvement
and at 6 months there was definite increase in the schirmer test & TBUT values. The results were not
influenced by the age & gender of the patients. In the control group though there was definite symptomatic
relief in all the patients, but there was no change in the major study parameters i.e. tear film meniscus
height; schirmer test and TBUT. At six month of the study there was marginal improvement of the major
parameters but there was a lot of difference between the test and control groups. Thus gamma linolenic
acid has a definite role in the management of dry eye.
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Keywords
Dry eye, Gamma linolenic acid, Loteprednol etabonate
Citation
Sharma Ashok K, Raj Hans, Pandita Archana, Tandon Vishal R, Mahajan Annil. Gamma Linolenic Acid in Dry Eye. JK Science Journal of Medical Education and Research. 2006 Jan-Mar;8(1): 24-27