Comparative Effect of Timolol, Levobunolol and Betaxolol on IOP in Patients of Chronic Simple Glaucoma
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Date
2005-04
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Abstract
In this prospective randomized parallel study we compared the effects of topical timolol maleate,
levobunolol hydrochloride and betaxolol hydrochloride on intraocular pressure (IOP) in the patients
of primary open angle glaucoma after 16 weeks of instillation as 1 drop 12 hourly in 0.5% concentration.
23 eyes of 16, 19 eyes of 12 and 20 eyes of 12 patients were included in timolol, levobunolol and
betaxolol groups respectively. Timolol, levobunolol and betaxolol lowered IOP by 13.05 ± 1.53, 14.05
±1.47 and 7.58 ± 0.90mmof Hg respectively after 6weeks and by16.12±1.67,16.28 ±1.85 and 8.535
± 0.983 mm of Hg respectively after 16 weeks (P<0.001). Both levobunolol and timolol produced
greater reduction in IOP than betaxolol (P<0.001). The results of our study indicated that betaxolol is
less efficacious in lowering IOP in Indian patients and could only be preferred over timolol in glaucoma
patients with associated chronic obstructed pulmonary disease (COPD) or bronchial asthma. However,
Levobunolol could be a better alternative to timolol , as being a longer acting agent with IOP control
for 24 hrs after single instillation and can be used as once a day instillation with better safety profile.
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Keywords
IOP, Glaucoma, Levobunolol, Betaxolol, Non-contact tonometer, Timolol
Citation
Sharma Rashmi, Kohli Kamlesh, Kapoor Bhuvneshwar, Mengi R K, Sadotra P, Verma Ujala . Comparative Effect of Timolol, Levobunolol and Betaxolol on IOP in Patients of Chronic Simple Glaucoma. JK Science Journal of Medical Education and Research. 2005 Apr-June;7(2): 1-4