Study of Fine Needle Aspiration Cytology in Lymphadenopathy with Special Reference to Acid-fast Staining in Cases of Tuberculosis
Loading...
Date
2005-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The present study was conducted to evaluate the usefulness of FNAC as a diagnostic tool in 1000
patients of lymphadenopathy. Fine needle aspiration was performed in all the patients following
through clinical examination and slides were stained with H & E, PAP and Ziehl Neelsen stains. The
results of FNAC were further correlated with paraffin embedded sections of tissue blocks. Eight
hundred and sixty-four cases (86.4%) were of benign lymphadenopathy; out of which 536 (53.6%)
cases were of reactive nature and 328 cases (32.8%) were tubercular. The remaining 136 (13.6%)
cases were of malignant lymphadenopathy, consisting 45 (4.5%) cases of primary malignancies i.e.
lymphomas and 91 (9.1%) cases of metastasis to lymph nodes. Out of 328 cases, Z-N positivity for
AFB was found in 152 cases (46.4%) and Mantoux test was positive in 180 cases (54.9%). On
correlation of FNAC findings with histopathology; sensitivity and specificity was found out to be
91.6% and 99%, respectively, with diagnostic accuracy of 97.3% in cases of benign lesions. The
same being 97%, 97.5% and 97.4%, respectively in tubercular lesions. The sensitivity, specificity
and diagnostic accuracy was 100% each in malignant lesions. FNAC of lymphnodes is an excellent
first line method, for investigating the nature of the lesions, as it is economical and convenient alternative
to open biopsy.
Description
Keywords
FNAC, Lymphnodes, Malignant, Tubercular, Reactive
Citation
Ahmad S Shamshad, Akhtar Shakeel, Akhtar Kafil, Naseem Shano, Mansoor Tariq. Study of Fine Needle Aspiration Cytology in Lymphadenopathy with Special Reference to Acid-fast Staining in Cases of Tuberculosis. JK Science Journal of Medical Education and Research. 2005 Jan-Mar;7(1): 1-4