Trace Minerals And Oxidative Stress In Diabetic Retinopathy.
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Date
2014-04
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Abstract
There is accumulating evidence showing relationship between trace elements and Diabetes
mellitus (DM). This study evaluated the role of magnesium, Zinc and other indices of peroxidative
status ie MDA, Vitamin C and Vitamin E in pathogenesis of Retinopathy in type 2 diabetes.
Seventy two type 2 diabetes cases were enrolled in the study, of which 42 were with
retinopathy and 30 without. Patients with nephropathy were excluded. Forty age- and sexmatched
subjects were served as health controls. The results showed that the mean values of
Mg and Zn were significantly lower reduced in diabetes more so in diabetic retinopathy cases
as compared to control subjects (p<0.05). Lipid peroxidation marker MDA was a significantly
higher in both the diabetes groups whereas serum Vitamin C and vitamin E levels were significantly
low (p<0.05) as compared to controls. Our correlation study revealed that MDA was
negatively associated with serum Mg (r=-0.73, p<0.01) as well as serum Zn (r= -0.82, p<0.01),
pointing towards the role of these trace elements in retarding the oxidative process prevailing
in diabetic retinopathy.
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Keywords
Trace elements, peroxidative status, diabetic retinopathy
Citation
Kumari S, Pradhan T, Panda T K. Trace Minerals And Oxidative Stress In Diabetic Retinopathy. Bangladesh Journal of Medical Science. 2014; 13(2): 175-179.