Protective effect of Nigella sativa against paracetamol induced hepatic and renal damages.
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Date
2015-05
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Abstract
Background: Non-steroidal anti-inflammatory drugs are very commonly used as an
analgesic, antipyretic, anti-inflammatory, and antiplatelet agent. They have significant
adverse effect on liver and kidney besides damaging stomach. Their effect on liver
and kidney are of serious concern. Hence, we have decided to study the preventive
effect of Nigella sativa against paracetamol induced hepatic and renal damages.
Methods: Ethanolic and aqueous extracts of N. sativa were prepared with the help
of Soxhlet’s apparatus. Totally, 36 wistar albino rats (150-200 g) of either sex were
divided into six groups of six each. Group I was administered with distilled water,
Group II-VI were treated with paracetamol 750 mg/kg i.p. Group III-VI were test
groups also treated with N. sativa aqueous extract (200 and 400 mg/kg p.o) and
ethanolic extract (200 and 400 mg/kg p.o), respectively. The treatment was given
daily for 7 days and on 8th all the rats were sacrificed and the blood was analyzed
for hepatic and renal function tests and tissue was preserved for histopathological
examination.
Results: Paracetamol administration caused a marked hepatic and renal damage,
which is evidenced by the increase in liver and renal function test parameters in
the negative control group. N.sativa extracts prevented this damage. The protective
was seen maximum in ethanolic extract followed by the aqueous extract in dosedependent
manner.
Conclusion: Ethanolic extract showed significant protection against paracetamolinduced
and renal damage.
Description
Keywords
Nigella sativa, Paracetamol, Hepatoprotection,, Nephroprotection
Citation
Hasan Mohammed N, Khan Rahat A, Nasiruddin Mohammed, Khan Aijaz A. Protective effect of Nigella sativa against paracetamol induced hepatic and renal damages. International Journal of Basic & Clinical Pharmacology. 2015 May-Jun; 4(3): 503-509.