Comprehensive review of anti-tubercular treatment induced liver injury.
Loading...
Date
2015-05
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The challenge in the management of tuberculosis is further compounded by the
liver injury associated with anti-tubercular treatment (ATT) drugs. The problem
of drug-induced liver injury (DILI) associated with ATT drugs is significant in the
developing countries because of high disease burden, limited monitoring due to scarce
resources and lack of awareness. There is heterogeneity in the pharmacokinetics and
pharmacodynamics of the various first line ATT drugs. There are various genetic and
environmental factors that affect DILI. Various guidelines have been proposed to
treat and monitor DILI. This article reviews the problem, risk factors, mechanism,
and management strategies of the DILI associated with ATT.
Description
Keywords
Drug-induced liver injury, Anti-tubercular treatment, Anti-tubercular treatment induced hepatotoxicity
Citation
Mohan Nandhini, Kumar Jitendra, Chakrawarty Avinash, Ranjan Piyush. Comprehensive review of anti-tubercular treatment induced liver injury. International Journal of Basic & Clinical Pharmacology. 2015 May-June; 4(3): 397-403.