Assessment of Mean Vessel Density and Angiogenesis in Endometrial Carcinomas.
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Date
2014-10
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Abstract
Objective: To evaluate the role of angiogenesis in tumor growth by the assessment of
mean vessel density and to quantify angiogenesis as an important variable in endometrial
cancers.
Material and Methods: 53 cases of endometrial malignancies (epithelial tumors-36 cases
and metastatic tumors-17 cases), were analysed for histological types, grades and
features like depth of invasion and vascular invasion. Microvessel counts were performed
by examining the microvessels thoroughly in terms of count, morphology and density after
staining the tissues by hematoxylin & eosin stain, reticulin and immunostain (Antifactor
VIII Ag).
Results: On H&E stain - Microvessel density (MVD) in endometrial malignancy ranged
from 3.0 - 13.5 and mean MVD was 8.78. On Reticulin stain - MVD ranged from 3.5 - 15.2
and mean MVD was 9.76. Antifactor VIII sections showed very small microvessels or
even single endothelial cells with the highest total counts and the MVD ranged from 6.5-
16.8 with Mean MVD of 11.7. The counts increased with the grade of the tumor in the
absence of necrosis or haemorrhage. MVD counts also increased with the stage, being 8.12 in Stage I disease, 8.65 in Stage II and 10.8 in stage III disease. Atypical hyperplasia
was found to be associated with epithelial tumors in 8 cases, making it a significant
finding.
Conclusion: Role of angiogenesis assumes greater significance with increasing severity
of lesions, higher grade and stage of the tumor and seems to have an important
diagnostic and prognostic significance.
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Keywords
Angiogenesis, endometrial carcinoma, microvessel density
Citation
Sherwani Rana K, Akhtar Kafil, Gupta Deepali, Mehdi Ghazala, Akhtar Nishat. Assessment of Mean Vessel Density and Angiogenesis in Endometrial Carcinomas. Cardiology and Angiology An International Journal. 2014 Oct-Dec: 2(4): 230-237.