Assessment of Mean Vessel Density and Angiogenesis in Endometrial Carcinomas.

Simple item page
dc.contributor.authorJelinek, Herbert F
dc.contributor.authorAl-Aubaidy, Hayder A
dc.contributor.authorMaschirow, Laura
dc.contributor.authorMeidinger, Sarah
dc.contributor.authorJamil, Dina A
dc.contributor.authorButkowski, Eugene
dc.date.accessioned2015-08-20T07:30:23Z
dc.date.available2015-08-20T07:30:23Z
dc.date.issued2014-10
dc.description.abstractObjective: To evaluate the role of angiogenesis in tumor growth by the assessment of mean vessel density and to quantify angiogenesis as an important variable in endometrial cancers. Material and Methods: 53 cases of endometrial malignancies (epithelial tumors-36 cases and metastatic tumors-17 cases), were analysed for histological types, grades and features like depth of invasion and vascular invasion. Microvessel counts were performed by examining the microvessels thoroughly in terms of count, morphology and density after staining the tissues by hematoxylin & eosin stain, reticulin and immunostain (Antifactor VIII Ag). Results: On H&E stain - Microvessel density (MVD) in endometrial malignancy ranged from 3.0 - 13.5 and mean MVD was 8.78. On Reticulin stain - MVD ranged from 3.5 - 15.2 and mean MVD was 9.76. Antifactor VIII sections showed very small microvessels or even single endothelial cells with the highest total counts and the MVD ranged from 6.5- 16.8 with Mean MVD of 11.7. The counts increased with the grade of the tumor in the absence of necrosis or haemorrhage. MVD counts also increased with the stage, being 8.12 in Stage I disease, 8.65 in Stage II and 10.8 in stage III disease. Atypical hyperplasia was found to be associated with epithelial tumors in 8 cases, making it a significant finding. Conclusion: Role of angiogenesis assumes greater significance with increasing severity of lesions, higher grade and stage of the tumor and seems to have an important diagnostic and prognostic significance.en_US
dc.identifier.citationSherwani Rana K, Akhtar Kafil, Gupta Deepali, Mehdi Ghazala, Akhtar Nishat. Assessment of Mean Vessel Density and Angiogenesis in Endometrial Carcinomas. Cardiology and Angiology An International Journal. 2014 Oct-Dec: 2(4): 230-237.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162160
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/4902en_US
dc.subjectAngiogenesisen_US
dc.subjectendometrial carcinomaen_US
dc.subjectmicrovessel densityen_US
dc.subject.meshBlood Vessels
dc.subject.meshEndometrial Neoplasms --blood
dc.subject.meshEndometrial Neoplasms --blood supply
dc.subject.meshHumans
dc.subject.meshMicrovessels --analysis
dc.subject.meshMicrovessels --metabolism
dc.subject.meshNeovascularization, Pathologic --metabolism
dc.subject.meshPatients
dc.titleAssessment of Mean Vessel Density and Angiogenesis in Endometrial Carcinomas.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
caij2014v2n4p230.pdf
Size:
1.04 MB
Format:
Adobe Portable Document Format
Description:
Original research article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Cardiology and Angiology: An International Journal