Evaluation of effect of topical ozone therapy on salivary Candidal carriage in oral candidiasis.
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Date
2015-03
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Abstract
Background and Aim: Ozone is highly valued for various therapeutic applications such as
antimicrobial, antihypoxic, analgesic, and immunostimulating for more than a century in the
medical profession. Ozone therapy is now gaining a strong foothold in dentistry. Ozone has
bactericidal, fungicidal, and virucidal properties. Oral candidiasis is one of the most common
opportunistic fungal infections of the oral cavity. Hence, a study was conducted to evaluate
and compare the ability of ozonated water and topical clotrimazole in reducing the Candidal
species colony‑forming unit (CFU) count in oral candidiasis.
Materials and Methods: The study included 40 candidiasis patients of either sex aged between
18 and 60 years attending the Department of Oral Medicine and Radiology. The patients were
randomly assigned to either topical ozone therapy or topical clotrimazole groups. Salivary
Candidal CFU counts were assessed during and after the treatments.
Results and Conclusion: There was gradual but significant reduction in Candidal CFU count in
both groups. At the end of the treatment, Candidal CFU count reduction in ozone group (60.5%
reduction) was more than the clotrimazole group (32.3% reduction). 14 patients (70%) with
candidiasis in ozone group were reduced to 6 (30%) whereas only 8 patients (40%) out of
13 (65%) in clotrimazole group, although intergroup comparison was not statistically significant.
Ozone therapy was much more effective in reducing the patients with candidiasis to a state of
carriers. These findings suggest that ozonated water might be useful to treat oral candidiasis.
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Keywords
Candidiasis, oral, ozone, saliva
Citation
Khatri Isha, Moger Ganapathi, Kumar N Anil. Evaluation of effect of topical ozone therapy on salivary Candidal carriage in oral candidiasis. Indian Journal of Dental Research. 2015 Mar-Apr; 26(2): 158-162.