Design and development of Orally Disintegrating Tablets of Famotidine Prepared by Direct Compression Method Using Different Superdisintegrants.
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Date
2011-03
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Abstract
Orally disintegrating tablets (ODT) are gaining popularity over conventional tablets due to their
convenience in administration and suitability for patients having dysphagia. Moreover no water is
required for swallowing the tablets and hence suitable for geriatric, pediatric and traveling patients.
Super disintegrants (such as Ac-Di-Sol, Crospovidone, sodium starch glycolate), Diluents (Dibasic
calcium phosphate) along with sweetening agent (aspartame) were used in the formulation of
tablets. The tablets were evaluated for hardness, friability, water absorption ratio, in-vitro
disintegration time (DT), in-vitro disintegration time in oral cavity and in vitro drug release. Using
the same excipients, the tablets were prepared by direct compression and were evaluated in the
similar way. Maximum drug release and minimum DT were observed with Crospovidone
excipient prepared by direct compression.
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Keywords
Orally disintegrating tablets, Ac-Di-Sol, Crospovidone, Dibasic calcium phosphate
Citation
Khinchi Mahaveer Pr, Gupta M K, Bhandari Anil, Sharma Natasha, Agarwal Dilip. Design and development of Orally Disintegrating Tablets of Famotidine Prepared by Direct Compression Method Using Different Superdisintegrants. Journal of Applied Pharmaceutical Science. 2011 Mar; 1(1): 50-58.