Subacute Sclerosing Panencephalitis in a Tertiary Care Centre in Post Measles Vaccination Era.
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Date
2009-09
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Abstract
This study was conducted to observe the impact of measles vaccination on the epidemiology of subacute sclerosing panencephalitis (SSPE) in the post measles vaccination era. This is a retrospective study from a tertiary care hospital, covering a ten year period starting a decade after the introduction of the national measles immunization programme in India. We analyzed 458 serologically confirmed SSPE cases. These patients had a high cerebrospinal fluid: serum anti-measles antibody ratio. The male to female ratio in the present study was 4.4:1. The mean age at onset of SSPE was 13.3 years, showing an increase in mean age at onset of SSPE. Clinical and other demographic details, available from 72 in-patients, are discussed in this report. Of these, a history of measles could be elicited in 34 cases. Mean latent period between measles infection and onset of SSPE was 7.8 years. Six patients gave a history of measles vaccination. A sizable percentage (15.5 %) of the patients was ≥ 18 years old and considered to have adult onset SSPE. The incidence of SSPE continues to be high and this report highlights the need for further strengthening routine measles immunization coverage.
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Keywords
SSPE, measles, serology, India
Citation
Malik Sonia, Dar Lalit, Broor Shobha, Gulati Sheffali, Salhotra Amandeep, Kalra Veena, Behari Madhuri. Subacute Sclerosing Panencephalitis in a Tertiary Care Centre in Post Measles Vaccination Era. Journal of Communicable Diseases. 2009 Sept; 41(3): 161-167.