HLA-DR phenotypes and lymphocyte response toM. Tuberculosis antigens in cured spinal tuberculosispatients and their contacts.
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Date
2004-04
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Abstract
Background: Our earlier studies on Human Leucocyte Antigens (HLA) in pulmonary tuberculosis patients revealed the
association of HLA-DR2 antigen with susceptibility to pulmonary TB and DR2 antigen has been shown to influence the
immunity to tuberculosis.
Objectives: The present study was carried out to find out whether HLA-DR antigens are associated with susceptibility
to spinal tuberculosis. Moreover, the role of HLA-DR antigens on lymphoproliferative response to Mycobacterium
tuberculosis culture filtrate antigens was studied using Lymphocyte Transformation Test (LTT).
Material and Methods: HLA-DR genotyping and lymphoproliferative response was carried out in 63 cured spinal TB
patients and 63 control subjects (spouses of pulmonary and spinal TB patients).
Results: A trend towards an increased frequency of HLA-DR9 antigen was observed in spinal TB patients compared to
controls. A significantly decreased lymphocyte response to M. tuberculosis antigens was observed in HLA-DR9 antigen
positive control subjects compared to HLA- DR9 antigen negative subjects (P=0.0009) whereas increased response was
observed with DR9 positive cured spinal TB patients compared to HLA-DR9 antigen negative patients. Further, HLADR3
antigen positive patients showed a decreased lymphocyte response compared to HLA-DR3 antigen negative
patients (P<0.05).
Conclusion: The study suggests that HLA-DR9 antigen either alone or in combination with other HLA antigen as
lhplotype and non-HLA genes may be associated with susceptibility to spinal TB and play a regulatory role on the
immune response to M. tuberculosis in spinal tuberculosis patients.
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Keywords
HLA-DR, lymphocyte response, M. tuberculosis antigen, cured spinal tuberculosis
Citation
Kurian Sunil Mathan, Selvaraj P, Reetha A M, Charles N, Narayanan P R. HLA-DR phenotypes and lymphocyte response toM. Tuberculosis antigens in cured spinal tuberculosispatients and their contacts. Indian Journal of Tuberculosis. 2004 Apr; 51(2): 71-76.