HLA-DR phenotypes and lymphocyte response toM. Tuberculosis antigens in cured spinal tuberculosispatients and their contacts.
| dc.contributor.author | Kurian, Sunil Mathan | |
| dc.contributor.author | Selvaraj, P | |
| dc.contributor.author | Reetha, A M | |
| dc.contributor.author | Charles, N | |
| dc.contributor.author | Narayanan, P R | |
| dc.date.accessioned | 2013-09-12T06:28:29Z | |
| dc.date.available | 2013-09-12T06:28:29Z | |
| dc.date.issued | 2004-04 | |
| dc.description.abstract | Background: Our earlier studies on Human Leucocyte Antigens (HLA) in pulmonary tuberculosis patients revealed the association of HLA-DR2 antigen with susceptibility to pulmonary TB and DR2 antigen has been shown to influence the immunity to tuberculosis. Objectives: The present study was carried out to find out whether HLA-DR antigens are associated with susceptibility to spinal tuberculosis. Moreover, the role of HLA-DR antigens on lymphoproliferative response to Mycobacterium tuberculosis culture filtrate antigens was studied using Lymphocyte Transformation Test (LTT). Material and Methods: HLA-DR genotyping and lymphoproliferative response was carried out in 63 cured spinal TB patients and 63 control subjects (spouses of pulmonary and spinal TB patients). Results: A trend towards an increased frequency of HLA-DR9 antigen was observed in spinal TB patients compared to controls. A significantly decreased lymphocyte response to M. tuberculosis antigens was observed in HLA-DR9 antigen positive control subjects compared to HLA- DR9 antigen negative subjects (P=0.0009) whereas increased response was observed with DR9 positive cured spinal TB patients compared to HLA-DR9 antigen negative patients. Further, HLADR3 antigen positive patients showed a decreased lymphocyte response compared to HLA-DR3 antigen negative patients (P<0.05). Conclusion: The study suggests that HLA-DR9 antigen either alone or in combination with other HLA antigen as lhplotype and non-HLA genes may be associated with susceptibility to spinal TB and play a regulatory role on the immune response to M. tuberculosis in spinal tuberculosis patients. | en_US |
| dc.identifier.citation | Kurian Sunil Mathan, Selvaraj P, Reetha A M, Charles N, Narayanan P R. HLA-DR phenotypes and lymphocyte response toM. Tuberculosis antigens in cured spinal tuberculosispatients and their contacts. Indian Journal of Tuberculosis. 2004 Apr; 51(2): 71-76. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/148227 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://medind.nic.in/ibr/t04/i2/ibrt04i2p71.pdf | en_US |
| dc.subject | HLA-DR | en_US |
| dc.subject | lymphocyte response | en_US |
| dc.subject | M. tuberculosis antigen | en_US |
| dc.subject | cured spinal tuberculosis | en_US |
| dc.title | HLA-DR phenotypes and lymphocyte response toM. Tuberculosis antigens in cured spinal tuberculosispatients and their contacts. | en_US |
| dc.type | Article | en_US |