Anticancer activity of merremia emarginata (Burm.F) against human cervical and breast carcinoma.
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Date
2012-10
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Abstract
Merremia emarginata Burm. F (Convolvulaceae) is a perennial, much branched herb (creeper). It is found widely distributed all over the India, specially in damp
places in upper gangetic plain, Gujarat, Bihar, West Bengal, Western‐ Ghats, ascending up to 900m in the hills, Goa, Karnataka in India, Ceylon and Tropical
Africa. Merremia emarginata is also known as Ipomoea reniformis chois. It is reported to have many important medicinal properties. In the Indigenous system of
Medicine, Ipomoea reniformis has been claimed to be useful for cough, headache, neuralgia, rheumatism, diuretic, inflammation, troubles of nose, fever due to
enlargement of liver and also for treating cancer. The present study was designed to evaluate the invitro anticancer activity of Merremia emarginata Burm.F. The
different solvent fraction of whole plant Merremia emarginata Burm.F was subjected for MTT assay. The ethylacetate fraction of whole plant was found to be
cytotoxic against human cervical carcinoma Hela cell lines and human breast carcinoma MCF cell lines. The IC50 value of ethylacetate fraction was 51.57μg/ml
against Hela cell lines and 39.6μg/ml against MCF-7 cell lines. Significant results were observed thereby justifying the use of plant in the traditional system of
medicine.
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Keywords
MTT assay, Anticancer activity, Merremia emarginata, cervical carcinoma, Breast carcinoma
Citation
Purushoth Prabhu T, Panneerselvam P, Selvakumari S, Ubaidulla Udhumansha, Shantha A. Anticancer activity of merremia emarginata (Burm.F) against human cervical and breast carcinoma. International Journal of Research and Development in Pharmacy and Life Sciences. 2012 Oct-Nov; 1(4): 189-192.