Deletion of ABL/BCR on der(9) associated with severe basophilia.
Loading...
Date
2011-05
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Chronic basophilic leukemia is a rare form in chronic myeloid leukemia patients. Only limited number of reports are available. Herein, we describe a patient who presented with fatigue, weight loss, leucocytosis, prominent basophilia, and mild eosinophilia. On biopsy, bone marrow was hypercellular with marked basophils. The immunophenotype showed abnormal expression of CD7, which is suggestive of basophilic maturation. Chromosomal analysis from GTG-banded metaphases revealed Ph positivity, and fluorescence in situ hybridization (FISH) with BCR/ABL dual color, dual fusion probe showed single fusion on the der(22) chromosome and ABL/BCR fusion was deleted on the der(9) chromosome. The deletion (ABL/BCR) on der(9) may be associated with basophilia which may be also indicative of the transformation of CML to acute myeloid leukemia.
Description
Keywords
Basophilia, BCR/ABL deletions, chronic myeloid leukemia
Citation
Vaidya Shantashri, Madkaikar Manisha, Ghosh Kanjaksha, Vundinti Babu Rao. Deletion of ABL/BCR on der(9) associated with severe basophilia. Indian Journal of Human Genetics. 2011 May; 17(2): 100-103.