Deletion of ABL/BCR on der(9) associated with severe basophilia.

Simple item page
dc.contributor.authorVaidya, Shantashri
dc.contributor.authorMadkaikar, Manisha
dc.contributor.authorGhosh, Kanjaksha
dc.contributor.authorVundinti, Babu Rao
dc.date.accessioned2012-06-11T08:53:54Z
dc.date.available2012-06-11T08:53:54Z
dc.date.issued2011-05
dc.description.abstractChronic basophilic leukemia is a rare form in chronic myeloid leukemia patients. Only limited number of reports are available. Herein, we describe a patient who presented with fatigue, weight loss, leucocytosis, prominent basophilia, and mild eosinophilia. On biopsy, bone marrow was hypercellular with marked basophils. The immunophenotype showed abnormal expression of CD7, which is suggestive of basophilic maturation. Chromosomal analysis from GTG-banded metaphases revealed Ph positivity, and fluorescence in situ hybridization (FISH) with BCR/ABL dual color, dual fusion probe showed single fusion on the der(22) chromosome and ABL/BCR fusion was deleted on the der(9) chromosome. The deletion (ABL/BCR) on der(9) may be associated with basophilia which may be also indicative of the transformation of CML to acute myeloid leukemia.en_US
dc.identifier.citationVaidya Shantashri, Madkaikar Manisha, Ghosh Kanjaksha, Vundinti Babu Rao. Deletion of ABL/BCR on der(9) associated with severe basophilia. Indian Journal of Human Genetics. 2011 May; 17(2): 100-103.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138945
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214311/en_US
dc.subjectBasophiliaen_US
dc.subjectBCR/ABL deletionsen_US
dc.subjectchronic myeloid leukemiaen_US
dc.subject.meshAdult
dc.subject.meshBasophils --analysis
dc.subject.meshChromosome Deletion
dc.subject.meshHumans
dc.subject.meshLeukemia, Myeloid, Acute --diagnosis
dc.subject.meshLeukemia, Myeloid, Acute --genetics
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --diagnosis
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --genetics
dc.subject.meshMale
dc.titleDeletion of ABL/BCR on der(9) associated with severe basophilia.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijhg2011v17n2p100.pdf
Size:
201.57 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Human Genetics