Pharmacokinetics of mefloquine in uncomplicated plasmodium falciparum malaria patients in Myanmar
No Thumbnail Available
Date
1995-08-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
With the aim to study the pharmacokinetic basis underlying the therapeutic outcome of mefloquine in malaria patients, a single oral dose of 1000 mg mefloquine hydrochloride (Mepha) was administered to 24 patients with acute uncomplicated falciparum malaria and 10 healthy volunteers and was followed-up till day 42. The drug serum levels at various time intervals were analysed by a Waters HPLC and the pharmacokinetic profile studied. The study shows that although Myanmar malaria patients had a slower rate of absorption (T1/2ab = 6.38 + 0.60 hour; Tmax =1.31 + 0.12 days), the peak serum level reached was much higher (Cmax = 2.24 + 0.05 ug/ml) than those of the westerners.
Description
Keywords
Citation
Thaw Zin, Ye Thwe, Tin Shwe, Thida Hmun, Nwe Nwe Yin, Thaung Hla. Pharmacokinetics of mefloquine in uncomplicated plasmodium falciparum malaria patients in Myanmar. Myanmar Health Sciences Research Journal. 1995; 7(2): 53-58