Pharmacokinetics of mefloquine in uncomplicated plasmodium falciparum malaria patients in Myanmar

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dc.contributor.authorThaw Zinen_US
dc.contributor.authorYe Thween_US
dc.contributor.authorTin Shween_US
dc.contributor.authorThida Hmunen_US
dc.contributor.authorNwe Nwe Yinen_US
dc.contributor.authorThaung Hlaen_US
dc.date.accessioned2009-06-30T08:37:30Z
dc.date.available2009-06-30T08:37:30Z
dc.date.created1995-08-01en_US
dc.date.issued1995-08-01en_US
dc.description.abstractWith the aim to study the pharmacokinetic basis underlying the therapeutic outcome of mefloquine in malaria patients, a single oral dose of 1000 mg mefloquine hydrochloride (Mepha) was administered to 24 patients with acute uncomplicated falciparum malaria and 10 healthy volunteers and was followed-up till day 42. The drug serum levels at various time intervals were analysed by a Waters HPLC and the pharmacokinetic profile studied. The study shows that although Myanmar malaria patients had a slower rate of absorption (T1/2ab = 6.38 + 0.60 hour; Tmax =1.31 + 0.12 days), the peak serum level reached was much higher (Cmax = 2.24 + 0.05 ug/ml) than those of the westerners.en_US
dc.identifier.citationThaw Zin, Ye Thwe, Tin Shwe, Thida Hmun, Nwe Nwe Yin, Thaung Hla. Pharmacokinetics of mefloquine in uncomplicated plasmodium falciparum malaria patients in Myanmar. Myanmar Health Sciences Research Journal. 1995; 7(2): 53-58en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/126808
dc.subject.meshPlasmodium Falciparumen_US
dc.subject.meshMalaria, Falciparumen_US
dc.subject.meshMefloquine-pharmacokineticsen_US
dc.subject.meshMyanmaren_US
dc.titlePharmacokinetics of mefloquine in uncomplicated plasmodium falciparum malaria patients in Myanmaren_US
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