The relationship between the intensity of malaria infections and different types of G-6-PD deficiency in children living in malaria endemic areas of Burma
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1989-04-01
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The sample consisted of 88 males and 159 females from Taikkyi and Thantaung townships. Subjects were school children under 14 years of age. Using WHO (1969) standard methods and recently developed cytochemical method (Van Noorden & Vogels 1985) 14 (15.9 per cent) G-6-PD deficient males (hemizygous), 7(4.4 per cent) homozygous females and 17(10.7 per cent) heterozygous females were detected. Out of 14 hemizygous males, 5 were positive with P. falciparum and 3 were positive with P. vivax. In 7 homozygous females, one was infected with P falciparum and two with P. vivax. Out of 17 heterozygous females, 6 were infected with P falciparum and two with P vivax P. falciparum parasitaemia in normal male was 6.0 per cent (mean of 19 subjetcs), male G-6-PD hemizygote was 1.0 per cent (mean of 5 subjects), female G-6-PD normal was 8.6 per cent (mean of 34 subjects), female G-6-PD homozygote was 1.2 per cent (one subject only), and female heterozygote was 1.0 per cent (mean of 6 subjects). P. vivax parasitaemia in male G-6-PD hemizygote was 1.0 per cent (mean 1.0 per cent (mean of 3 subjects), female G-6-PD normal was 6.2 per cent (mean of 9 subjects), female G-6-PD heterozygote was 1.0 per cent (mean of 2 subjects). The cytochemical staining method was also used to distinguish the intensity of malarial parasites in individual cells of heterozygotes. It was observed that the malaria parasites infect both G-6-PD deficient and normal cells but parasitaemia was significantly and uniformly lower in deficient cells (normal cells = 0.8 + or - SE 0.ll8; dificient cells = 0.4 + or - SE 0.052) (P<0.01).
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Myint Oo, Cho Cho Oo, Myint Lwin, Wai Wai Naing, Maung Mon. The relationship between the intesity of malaria infections and different types of G-6-PD deficiency in children living in malaria endemic areas of Burma. Burma Health Sciences Research Journal. 1989; 1(1): 1-8