People's Journal of Scientific Research
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Published by People's Group (India) © 2005, the largest hub of education and healthcare in central India.
ISSN: 0974-6358
Our mission is:
ISSN: 0974-6358
Our mission is:
- To understand the fundamental disease mechanism and identification of modifier genes, return benefits to patients through improved diagnostic capacity, better disease management and the development of rational treatments.
- To prevent and cure genetic diseases.
- To improve the lives of people living with thalessemia, cancer, diabetes, heart disease, and other disabling diseases through intense scientific research.
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Item Endocrown: An Innovative Approach for Grossly Destructed Tooth(People's University, 2024-12) Sharma, D; Mathur, M.Endodontically treated molar rehabilitation is still difficult. The mechanical properties of molars are lost during endodontic treatment. As a result of the pulp and surrounding dentin tissues being removed, they become brittle. When repairing molars with significant coronal loss and endodontic treatment challenges, endocrown, a single partial restoration, may be an excellent option.Item Misdiagnosed Case of Adenomatoid Odontogenic Tumour in a Young Female(People's University, 2024-12) Kakkad, A; Dhimole, A; Tiwari, S; Ghate, SM.A misdiagnosed case of Adenomatoid Odontogenic Tumour (AOT) which is clinically and radiographically diagnosed but due to lack of proper knowledge of pedodontics the case had not been treated properly and the lesion had become aggressive. The purpose of this case is to represent clinical and radiographic findings of AOT for education purposes. It's a misdiagnosed case of AOT in a young female patient. Surgical excision was done in the present case and no reoccurrence was reported. The present case was misdiagnosed by a pedodontist. We suggest that the cases in which there is a suspicion of a bigger or more aggressive pathology the opinion of an oral radiologist and oral pathologist always should be sought.Item 3 D Printing: Its Applications in Pediatric Dentistry Practice(People's University, 2024-12) Kaushik, N; Srivastava, N; Rana, V; Pruthi, T; Kaur, N.Digital dentistry is a concept getting more and more contour nowadays, due to the latest technological advancements registered in the field. This paper makes a review of one of the newest digital technology, 3D Printing which is in its nascent stage to prove usefulness in Pediatric Dentistry. This technology would help in diagnosis, or would simplify procedures for both pediatric dentist and patient, and thus would contribute significantly in increasing the quality of the therapeutic act.Item Addressing Problems of Oral Pathology Students after Improving Teaching Learning Methods(People's University, 2024-12) Kavle, P; Sangala, BN; Buva, KB; Masne, SP; Sachdev, SS.Background- Oral Pathology and Oral Histology as academic subjects is concerning. Despite significant advancements through books, the internet, and conferences, gaps remain in students' understanding and interest in these fields. This may partly stem from the perception that these are non- clinical subjects with limited practical career opportunities. We thought of introducing latest teaching and learning methods to improve the students understanding and make it more interesting. Materials& Methods- The cross-sectional questionnaire based study was done with BDS students, to gauge the understanding of their knowledge in the subject of Oral Pathology and Oral Histology after introduction of advanced teaching learning methods. There were 15 multiple choice questions. The data recorded was analyzed using frequency distribution. Results- There were very positive results with new methods and it was evident in the understanding of the subject by the students. Conclusion-Our study revealed that students generally have a good overall understanding of Oral Pathology. However, they do face certain challenges that can be easily addressed with appropriate measures. Through this research, we aim to raise awareness among readers about the evolving trends in teaching learning and encourage their regular incorporation into practice.Item A Review-Obstructive Sleep Apnea(People's University, 2024-12) Talera, D; Arya, G; Shinde, C; Handa, H.Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial or complete collapse of the upper airway during sleep, resulting in reduced or absent airflow lasting for at least 10 seconds and associated with either cortical arousal or a fall in blood oxygen saturation. OSA is associated with major comorbidities including daytime somnolence, impaired cognition, poor quality of life. OSA is an independent risk factor for a variety of cardiovascular diseases such as hypertension, atrial fibrillation, etc. Specialized diagnostic modalities include CBCT, CT, MRI, cephalometry. The gold standard is polysomnography. Management include behavioral modification, weight loss, medication, continuous positive airway pressure, oral appliance therapy, and surgical procedures. This article briefly describes the pathophysiology and its effects on the day to day life, various diagnostic modalities and management of OSA.Item Beyond Toothpaste: The Role of Intraoral Fluoride Devices in Oral Health Maintenance(People's University, 2024-12) Nagappan, JS; Dhanabalan, O; Subhalakshmi, V; Parthasarathi, S.Dental caries remains a significant concern, particularly among medically compromised individuals, those with mental disabilities, and the elderly. Fluoride has long been utilized as a preventive measure against dental caries through various modalities, including water fluoridation, systemic intake, and topical applications. Intraoral fluoride-releasing devices represent an innovative advancement in preventive dentistry, offering a targeted and sustained approach to reducing caries incidence. These devices provide controlled, long-term fluoride release directly into the oral cavity, ensuring optimal fluoride levels in saliva and dental plaque. This mechanism supports enamel remineralization, inhibits demineralization, and suppresses the activity of cariogenic bacteria. Diverse designs, such as fluoride- releasing elastomers, polymer-based systems, and bioadhesive materials, have demonstrated effectiveness in both clinical and experimental settings. This review examines the types and clinical applications of intraoral fluoride-releasing devices, emphasizing their role in caries prevention and potential directions for future research.Item Infant Oral Health: A Literature Review(People's University, 2024-12) Kapoor, S; Rana, V; Srivastava, N; Kaushik, N; Pruthi, T.The American Academy of Pediatric Dentistry and the American Academy of Pediatrics advise that children undergo dental examinations and assessments within their first year of life. Early dental visits evaluate a child's risk status through parental interviews and oral examinations. Infant oral health plays a crucial role in a child's overall development. This article offers a concise overview of different aspects of oral health care for children, highlighting perinatal oral health care, anticipatory guidance, the concept of a dental home, the first dental visit, oral health examinations, dietary counseling, and therapeutic interventions for relevant oral issues, including teething. It serves as the foundation for lifelong preventive education and dental care, aimed at achieving optimal oral health throughout childhood.Item Management of Extra Oral Sinus with Non-Surgical Endodontic intervention(People's University, 2024-12) Baror, S; Sharma, DK.Extra oral sinus tracts of endodontic origin clinically, might be mistaken with a variety of illnesses. Differential diagnosis of this clinical problem is critical in delivering proper clinical care because misdiagnosis may result in healing failure or needless medications. As a result, every cutaneous sinus tract involving the face or neck should be investigated for dental causes. Its diagnosis is not usually straightforward unless the treating clinician considers the possibility of a dental etiology. Once the accurate diagnosis has been made, definitive treatment, such as root canal therapy and tooth extraction, to remove the cause of infection is simple and successful.Item Oral Manifestation in Gastro-Oesophageal Reflux Disease - A Short Study(People's University, 2024-12) Shilpa, B; Sheela; Sangeetha, S.Background: Gastroesophageal reflux disease is a common condition that results from the reflux of gastric material through the lower esophageal sphincter into the esophagus or oropharynx. The aim of the present study was to assess oral manifestations in gastero-oesophageal reflux disease by endoscopy. Materials & Methods: The prospective study was carried in the department of Oral Medicine & Radiology. The study group consisted of 50 patients with Gastroesophageal reflux disease. The presence/absence of various indicators was evaluated for each patient. Results: We observed that sensitivity and halitosis were most prevalent while tooth wear was least observed. In our study we found halitosis was found in more than 90% of cases. Conclusion: In conclusion, our study suggests that Xerostomia is a significant clinical symptom of GERD patients and erythema of soft palate/uvula, tooth wear is significant clinical sign of GERD patients.Item Middle Mesial Canal: A Special Consideration for Mandibular Molars(People's University, 2024-12) Pande, PR; Srivastava, AA.Thorough debridement is required for the whole root canal system for successful endodontic therapy. One factor contributing to inadequate canal cleaning may be the complex root canal architecture. The mandibular molars exhibit significant differences in terms of additional roots or canals. With the use of any magnification devices, the clinician should strive to locate every potential channel. The middle mesial canal changes in mandibular molars are covered in this report.Item Serum Protein Levels as Potential Biomarkers in Oral Cancer and Oral Precancer(People's University, 2024-12) Mhatre, VS; Dhumal, SN; Nandvanshi, S; Patil, PT; Choudhari, S.Background:The reactive free radicals may interact with intracellular macromolecules such as proteins leading to carcinogenesis. This study was conducted to assess the use of proteins as potential biomarkers in oral premalignant and malignant lesions. Materials & Methods: This study was conducted on 15 individuals with oral potentially malignant disorders, 15 patients with oral cancer, and 15 healthy controls. Results: Our results showed that serum protein levels were decreased in OPMDs, but increased in Oral cancer. Conclusion: It may be concluded that serum protein can be used a potential biomarker for Oral precancer and oral cancer.Item Tumor-Specific Immunity: The Promise of Cancer Vaccines(People's University, 2024-01) Mhaske, S; Saha, S; Jedhe, SCancer vaccines are a potentially effective way to improve the effectiveness of cancer immunotherapy. They are designed to elicit tumor-specific cellular immunity by antigen presentation by dendritic cells. Tumor-associated antigens (TAAs) have been given top priority by the National Cancer Institute as targets for cancer vaccines. AIA stands for "Adoptive Immune Activation." This approach involves transferring immune cells that have been activated and expanded outside the body back into the patient to target and eliminate cancer cells. The AIA took into account a number of parameters, including therapeutic efficacy, immunogenicity, carcinogenicity, specificity, expression level, and positive cell rate. The spectrum of cancer vaccines is delved in this paper, which covers their creation, modes of action, clinical uses, and future directions.Item Herpes associated Erythema Multiforme in Young Child- A Case Report(People's University, 2024-01) Verma, S; Kumari, P; Bhimwal, P; Naik, SRErythema multiforme (EM) is a mucocutaneous disorder that presents clinically as vesiculobullous and ulcerative lesions affecting any part of oral cavity when occurring alone in oral cavity. It can commonly be seen on skin too with typical target like lesions. We present a case of EM in a 9 year old girl who complained of recurring lesions on lip. Based on history, clinical presentation and serological investigations, it was diagnosed as herpes associated Erythema multiforme (HAEM). This case was very well managed with systemic steroids and it highlights the advantage of gentian violet for mucocutaenous lesions and also immunomodulator as maintenance therapy.Item The Role of Lasers in Dentistry: Advancements, Applications, and Future Prospects(People's University, 2024-01) Azad, A; Mishra, P; Siddique, MAB; Tyson, KLasers have revolutionized the practice of dentistry, offering precise and minimally invasive solutions across various dental specialties. This comprehensive review explores the historical evolution, fundamentals, applications, challenges, and future prospects of lasers in dentistry. Beginning with a historical overview, the review discusses the fundamental principles of laser-tissue interaction and the types of lasers commonly used in dental practice. It then delves into the diverse applications of lasers in conservative dentistry, periodontology, oral surgery, endodontics, pediatric dentistry, and orthodontics, highlighting their roles in cavity preparation, soft tissue management, disinfection, and surgical procedures. Despite their numerous advantages, challenges such as cost, learning curve, tissue interaction limitations, and regulatory considerations hinder the widespread adoption of lasers in dentistry. However, ongoing research and technological advancements continue to address these challenges, paving the way for enhanced patient care, improved treatment outcomes, and expanded applications of lasers in dentistry. Overall, lasers represent a promising toolset in modern dentistry, offering clinician's precision, efficiency, and patient comfort in various dental proceduresItem Artificial Intelligence-Powered Pediatric Dentistry: A Glimpse into the Future(People's University, 2024-01) Taiwade, A; Tiwari, S; Mali, S; Suganya, MThe rapid digitalization of various aspects of life has significantly transformed dentistry, improving the quality of dental care through advanced technologies like artificial intelligence (AI). AI, which replicates human cognitive processes, has revolutionized dental practices by automating timeconsuming tasks and offering precise diagnostics and treatment plans. Despite being in early development stages, AI in dentistry signifies a disruptive technology poised to redesign clinical care. Innovations such as CAD/CAM systems, intraoral imaging, and digital radiography illustrate AI's applications in caries diagnosis, implant design, etc. Historical milestones, from conceptualization of AI to advancements in machine learning and neural networks, have paved the way for sophisticated AI models used in various dental specialties, including pediatric dentistry. AI's potential extends to patient education and practice management, promising a future where dentistry is increasingly efficient, accurate, and patient-centered. This review highlights role of AI in pediatric dentistry with special mention of review of literature.Item Ectodermal Dysplasia - A Case Report and Comprehensive Literature Review(People's University, 2024-01) Gowda, Venkatesha RR; Rajaram, Mohan K; Fenn, SM; Ganesan, VEctodermal dysplasia (ED) is a rare genetic condition characterized by a variety of deformities in ectodermal derivatives. Skin, nails, hair, teeth, and exocrine glands are derived from ectodermal germinal layers during the development of an embryo. ED has been reported in more than 150 variants in the literature. An average of seven cases are reported for every 100,000 live births. anhidrotic (Hypohidrotic) and hydrotic ED are the two types based on the degree of function of sweat glands. A 42-year-old male with characteristic features of ectodermal dysplasia visited our dental department and was treated with complete denture prosthesis described in this case report.Item A Systematic Review on the use of Teledentistry in Pediatric Dentistry(People's University, 2024-01) Suganya, M; Mali, S; Rao, USM.Delivering oral healthcare to children can be challenging due to anxieties, access limitations, and geographical barriers. Teledentistry, the use of telecommunication technologies for dental care, has emerged as a potential solution. This systematic review evaluates the effectiveness of teledentistry in pediatric dentistry. Acomprehensive search of electronic databases, including PubMed, EMBASE, Scopus, and Web of Science, was conducted to identify relevant studies published with no time frame. The validity of teledentistry for oral screening varies with sensitivity and specificity. Studies also reported acceptable agreement between teledentistry and in-person examinations, with Kappa statistics. Teledentistry shows promise as a comparable tool to traditional methods for oral screening in pediatric dentistry. It holds particular value for school-based programs, remote areas, and long-term care facilities, potentially improving access to dental care for children. Further research with robust methodologies is needed to definitively determine the effectiveness of teledentistry across the full spectrum of pediatric dental care.Item All Lymphadenopathies are not Tubercular(People's University, 2024-01) Sureka, MM; Patel, A; Choubey, PLymphadenopathy refers to swelling of lymph nodes. Submandibular nodes (<1 cm) are often palpable in healthy children and young adults; healthy adults may have palpable inguinal nodes of up to 2 cm, which is considered normal. Lymphadenopathy can be localized or diffuse.Lymphadenopathy may be either primary or secondary manifestation of numerous disorders such as infectious diseases, immunologic diseases, malignant diseases (hematologic or metastatic), etc. In clinical practice, more than two-thirds of patients with lymphadenopathy have nonspecific causes or upper respiratory illnesses (viral or bacterial), others are benign while <1% are malignant. Detailed medical history, clinical examination, along with the lymph node examination, routine & special investigations are done. We report 2 cases of lymphadenopathy which were diagnosed as lymphomaItem Prevalence and Correlation of Oral Potentially Malignant Disorder Among Tobacco and Arecanut Users in Gwalior District(People's University, 2024-01) Sharma, YK; Vaid, S; Sargaiyan, V; Sharva, V; Gupta, P; Sharma, HDBackground- Oral cancer can arise from potentially malignant illnesses through a series of stages, including genetic, epigenetic, and metabolic changes. Some risk factors that increase the risk of developing oral cancer include using tobacco products, especially smokeless tobacco (SLT). The aim of this study was to find correlation & prevalence of oral potentially malignant disorder in tobacco and areca nut user's people residing in Gwalior district. Materials & Methods- A cross-sectional study with a descriptive design was carried out on 3042 participants. The study participants were selected from screening camps and in a hospital environment using simple random sampling. A survey was conducted to gather information on sociodemographic traits, different risk factors for oral cancer, and the existence of the disease's symptoms. The research investigator thoroughly examined each participant's oral cavity in accordance with WHO criteria for the early detection of OPMD. Results- the prevalence of OPMD was 4.27% among tobacco users. OSMF accounted for 1.58% of all cases. Tobacco users had a 3.241-fold increased incidence of OPMD (CI-0.041-0.303, p-0.01). The consumption of areca nut has increases the incidence of OPMD by 7.17 (CI: 0.747-6.503, p-0.001) times. Alcohol raises the risk of OPMD by 1.51 (CI- 0.002-0.128, p-0.05) times. Males had a 2.54 (1.10- 2.42,p-0.01) times increased chance of getting OPMD. Age group 18-30 showed 1.84 (1.32-2.15, p0.001) times higher chance of developing OPMD. Conclusion- The research reaffirms that the usage of drugs including alcohol, tobacco, and areca nut is one of the modifiable risk factors for OPMLItem Comparison of Ki-67 Expression in Leukoplakia and Squamous Cell Carcinoma-A Retrospective Study(People's University, 2024-01) Rathod, P; Singh, A; Nagi, RBackground: Oral malignancy is the most common malignancy worldwide. In India, approximately 77000 new cases are diagnosed and 52000 deaths are reported annually. Absolutely, understanding the molecular pathogenesis of conditions like oral leukoplakia can indeed be a game-changer in terms of early diagnosis and prognosis. Cell proliferation, which is tightly regulated in healthy tissues, can go haywire in cancer, leading to uncontrolled growth and tumor formation. By studying the molecular mechanisms underlying this dysregulation, researchers can identify potential biomarkers for early detection and develop targeted therapies to intervene in the progression of the disease. In the present study Ki-67 expression was compared between lesions of leukoplakia and Oral squamous cell carcinoma. Grades of epithelial dysplasia and Oral squamous cell carcinoma were also evaluated. Materials & Methods: This retrospective study conducted at our institution, represents a significant effort to understand the proliferative activity in oral lesions. With a total sample size of 135, including 72 oral leukoplakia samples, 50 oral squamous cell carcinoma samples, and 13 normal mucosal samples, it provides a comprehensive view of Ki-67 expression in different oral conditions. Results: The finding of over expression of Ki-67 with increasing grades of Oral Epithelial Dysplasia and in Oral Squamous Cell Carcinoma compared to normal mucosa was significant (p-value<0.05) and aligns with the known biology of these conditions. Conclusion: The conclusion drawn from our study suggests that Ki-67 expression could indeed serve as a reliable marker for predicting the future outcome of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.