National Journal of Medical Research

Permanent URI for this collection

https://imsear.searo.who.int/handle/123456789/149655

Editor in Chief: Dr. Viren Patel

ISSN: 2249 4995 (Print)

Frequency: 4 issues a year

Language: English

Online peer reviewed journal

Web site: https://njmr.in/

Browse

Now showing 1 - 20 of 72

Acute Hypoxic Respiratory Failure Secondary to Pulmonary Nocardiosis: An Unusual Presentation in the Emergency Department
(Medsci Publications, 2024-10) Chakravarty, MP; Singh, A; Sachan, S; Umar, H.
Background: Nocardiosis, a rare but serious infection caused by Gram-positive, aerobic actinomycetes, primarily affects immunocompromised individuals. This report highlights an uncommon case of pulmonary nocardiosis in an immunocompetent patient leading to acute hypoxic respiratory failure. Case Presentation: A 45-year-old male gardener with no significant past medical history presented with acute dyspnea, pleuritic chest pain, fever, night sweats, and weight loss. Physical examination revealed respiratory distress and hypoxia. Imaging showed bilateral alveolar infiltrates and cavitary lesions. Sputum analysis identified Gram-positive branching filamentous bacteria, and Nocardia species were cultured. HIV test was negative. Management: The patient was admitted to the ICU and treated with high-flow oxygen therapy and empirical antibiotics (trimethoprim-sulfamethoxazole [TMP-SMX] and meropenem). Upon culture results, TMP-SMX was continued, and meropenem was discontinued. The patient showed significant improvement and was discharged on oral TMP-SMX for a six-month course. Discussion: This case underscores the importance of considering pulmonary nocardiosis in acute respiratory failure, even in immunocompetent patients. Early diagnosis and appropriate treatment are crucial for favorable outcomes. Conclusion: Pulmonary nocardiosis can cause severe respiratory symptoms in otherwise healthy individuals. Prompt recognition and treatment are essential to manage this potentially life-threatening condition effectively.
Alterations in Thyroid Hormone Levels in Children with Protein-Energy Malnutrition
(Medsci Publications, 2025-06) Oinam, PD; Takhelmayum, PS; Wahengbam, DD; Moirangthem, M; Maisnam, AS
Background: Nutritional deficiencies are among the most significant public health challenges in India and other developing nations. Among those nutritional diseases, the Protein Energy Malnutrition (PEM) is the most prevalent one, affecting a large population especially children under five and is a major cause of morbidity and mortality. Aims and Objectives: To estimate serum total thyroxine (TT4), total tri-iodothyronine (TT3), thyroid stimulating hormones (TSH) in normal controls and children with PEM. To find out relationship between thyroid hormones and different grades of PEM. Methodology: Fifty children below 12 years of age suffering from different grades of protein energy malnutrition admitted in Pediatric ward, RIMS, Imphal, were selected as cases. Fifty healthy children, closely matched for age and gender, formed the control group. The study was carried out over a 24-month period, beginning in September 2016 and concluding in August 2018. Total thyroxine (TT4) and total trio-iodothyronine (TT3) were estimated by ELISA. Results: Serum thyroid hormones (TT3, TT4 and TSH) were significantly decreased in PEM when compared with controls. Among the different grades of PEM, total tri-iodothyronine (TT3) level was significantly low in Marasmic kwashiorkor children (0.61±0.14) whereas undernutrition group has the lowest value of Total Thyroxine (5.31±0.65) and TSH (1.60±0.81). Conclusion: A decrease in circulating thyroid hormone levels was linked to the severity of PEM. All the PEM cases should undergo a screening for thyroid hormone status which is essential for proper growth and health of the children.
Assessing Job Stress Among Emergency Department Healthcare Professionals in India: A Cross-Sectional Study
(Medsci Publications, 2025-06) Maithreyi, K; Kumar, SSV; Rao, HT AP
Background: Emergency healthcare professionals work in high-stress environments, facing long hours, traumatic events, and limited resources, resulting in psychological and physiological distress. This study assesses job-related stress among emergency healthcare providers in India and identifies key stressors. Methods: A cross-sectional study was conducted from March to June 2024, including 114 emergency healthcare workers. Stress levels were measured using the Stress Parameters and Manifestations Scale (SPMS), a 20-item tool assessing self-awareness, interpersonal relationships, psychosomatic symptoms, and clinical manifestations on a 5-point Likert scale. Higher scores indicate greater stress. Data were analyzed using SPSS 23.0, with t-tests and ANOVA, and significance set at p <0.05. Results: The cohort comprised 52.2% males, 80.5% doctors, and 71.7% from medical colleges. High workload perception (62.0%), sleep disturbances (41.6%), and low mood post-patient interactions (42.4%) were prevalent. Psychosomatic symptoms such as palpitations (40.7%) and persistent sleepiness (42.5%) were common. Females reported significantly higher self-awareness (p <0.001) and overall stress (p = 0.023). Those working over 16 hours daily had the highest stress, particularly in clinical manifestations (p = 0.017). Conclusion: Emergency healthcare workers experience significant occupational stress, highlighting the need for structured schedules, mental health support, and stress management strategies to improve workforce resilience.
Assessing Prevalence and Severity of Dry Eye Disease Across Various Types of Allergic Conjunctivitis
(Medsci Publications, 2024-10) Arora, P; Mehrotra, N; Tripathi, S; Yadav, M.
Background: Allergic conjunctivitis (AC) is a prevalent ocular condition triggered by environmental allergens, causing significant discomfort and reduced quality of life. Dry Eye Disease (DED), marked by ocular discomfort and visual disturbances, frequently overlaps with AC symptoms. This study examines the prevalence of DED in AC patients and explores the relationship between different AC types and DED severity. Method: A cross-sectional, observational study was conducted from June to September 2023 in the Department of Ophthalmology at a tertiary center in North India. A total of 264 AC patients aged 18 years and older with itchy eyes were included. Patients with contact lens use, recent ocular surgery, trauma, corneal pathology, or certain systemic diseases were excluded. DED was assessed using the Ocular Surface Disease Index (OSDI), Schirmer’s test, and Tear Film Break-Up Time (TFBUT). Results: DED was found in 70% of AC patients, with 20% mild, 19% moderate, and 32% severe cases. Females were more affected (64%). VKC patients showed higher tear production and better TFBUT scores. PAC patients had the most severe DED. Conclusion: DED is common in AC patients, with PAC associated with more severe DED, while VKC shows milder symptoms. Tailored treatment approaches are needed for managing AC and DED.
Assessment of Lest Ventricular Hypertrophy and Left Ventricular Diastolic Dysfunction Cardiovascular in Patients of Chronic Renal Failure by Echocardiography
(Medsci Publications, 2022-10) Chaudhary, Mahipal; Hadiya, Kaushik; Kothari, Prafful; Choudhary, Ashok
Introduction: Chronic renal failure, regardless of the cause, is the presence of kidney damage or a reduced level of kidney function for three months or longer. It is a group of signs and symptoms brought on by slow and long-term renal damage. The most frequent cardiovascular finding in people on dialysis is LVH. Objective: The study was conducted to estimate the prevalence of left ventricular hypertrophy and left ventricular diastolic dysfunction by echocardiography in patients with chronic renal failure. Method: This was an observational cross-sectional study at the Department of General Medicine among IPD patients, Tertiary Care Hospital, Surat. Result: Left ventricular hypertrophy out of 34 cases 22 (64.71%) cases were show left ventricular hypertrophy with an odd ratio of 3.208 (1.049, 9.81) and a p-value 0.0378 which was statically significant. prevalence of diastolic dysfunction was 79%. comparison of renal function test and echocardiographic change of chronic renal failure. In the renal function test serum, creatinine and EGFR were show a p-value < 0.001 which was statistically significant. Conclusion: Cardiac dysfunction and LVH are frequently noted in individuals with chronic renal failure at the time of commencement of dialysis. cardiovascular abnormalities in the form of LVH and diastolic dysfunction which antedate severe systolic dysfunction are frequently observed in milder degrees of chronic renal failure
Assessment of Perception about Immunization Among the Mothers of Under-Five Children at Urban Slum Area of Vijayapura City
(Medsci Publications, 2022-04) Ganganahalli, Praveen; Tellur, Laxmi; Patil, Santosh D; Yankanchi, Sandeep
Introduction: Immunization is one of the most cost-effective health investments worldwide. The World Health Organization (WHO) launched the expanded programme on immunization (EPI) in 1974 with the aim of immunizing children throughout the world. Objective: Assessment of perception about immunization among the mothers of under-five children at urban slum area of Vijayapura city. Methods: Cross-sectional study was conducted in Urban Field practice area of Community Medicine department among the mothers of under-five children residing permanently in the area and were interviewed regarding the perception about immunization to their children by using pre-structured proforma. Results: level of knowledge & perception was found average (around 50%). Nearly 40 to 60% of the participants agreed to the statements which signifies the immunization is very important to the child’s growth and development and should not be avoided. Conclusions: Providing mothers of under-five children with information about vaccination effectively increases the immunization coverage and was highly cost-effective also
Association of Serum Level of Vitamin D3 and Pulmonary Function in Bronchial Asthma Patients in A Tertiary Care Hospital of South Gujarat, India
(Medsci Publications, 2022-10) Parmar, Priyank; Dutt, Neha; Desai, Bijoy; Dhangar, Vandana
Introduction: Asthma is a chronic lung disease characterised by reversible airway obstruction, cellular infiltration, and airway inflammation. The reaction is characterised by the interaction of genetic and environmental variables, as well as the activation of cells in the innate and adaptive immune systems. Method: The study was conducted in the Department of General medicine, in Tertiary Care Center, to study association of serum level of Vitamin D3 and pulmonary function in bronchial asthma patients. As per inclusion and exclusion criteria ,137 patients of bronchial asthma were included in the study. Result: In cases having serum vitamin D3 level <20 ng/ml mean value of FVC, FEV1, FEV1/FVC ratio, was 108.10�.89, 68.56�.40, and 62.35�17. In cases having serum vitamin D3 20-29 ng/ml, mean value of FVC, FEV1, and FEV1/FVC ratio was 109.72�.22, 72.34�.48, and 64.39�97. In cases having serum vitamin D3 >30 ng/ml mean value of FVC, FEV1, and FEV1/FVC ratio, was 115.0�27, 81.0�09, and 70.52�00. Conclusion: Vitamin D3 deficiency was highly prevalent in asthmatic patients, there was a strong correlation between asthma severity and vitamin D3 concentrations and there was a direct and a positive significant correlation between vitamin D3 levels and pulmonary function test in asthmatic patients.
A Case Control Study of Vitamin D Levels in Chronic Obstructive Pulmonary Disease Patients and Healthy Volunteers in South Gujarat, India
(Medsci Publications, 2022-10) Patel, Kunal A; Patel, Parth H; Vaid, Manan P; Dandge, Vinod
Introduction: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) programme states that COPD is a common, treatable, and preventable disease that is characterized by a persistent airflow restriction that usually progresses and is connected to an exaggerated chronic inflammatory response in the airways and the lung to harmful particles or gases. The combined severity of a patient's co-morbid illnesses and exacerbations increases. The purpose of the study was to assess the vitamin D status of COPD patients and healthy participants. Methodology: This case-control study was conducted among 75 cases and 75 control at the Surat Municipal Institute of Medical Education and Research General Medicine department. Result: The mean vitamin D of subjects in cases was 32.21 � 12.68 and it was 52.05 � 1.99 in controls. The difference in vitamin D between the two groups was statistically significant (P Value<0.001). Conclusion: COPD patients had lower amounts of vitamin D. As COPD severity increases, vitamin D levels decrease. Along with a rise in COPD exacerbations, vitamin D levels are also decreasing
A Case Report on Musculoskeletal Melioidosis
(Medsci Publications, 2025-06) Kundu, S; Deb, S; Mallick, T; Bhattacharjee, SG
Melioidosis, caused by Burkholderia pseudomallei, is an underdiagnosed infection in India with a high case fatality rate if untreated. We report a case of a 59-year-old diabetic male farmer from West Bengal who presented with fever and respiratory distress. Initial empirical therapy with cefoperazone-sulbactam failed to improve his condition. Subsequently, he developed acute pain and swelling in the left shoulder. Imaging revealed osteomyelitis with intraarticular and periarticular abscesses. Surgical debridement and culture studies confirmed B. pseudomallei, identified using Ashdown’s medium, Gram staining, biochemical tests, and automated Vitek 2 analysis. The organism exhibited resistance to ceftazidime but was susceptible to meropenem and doxycycline. Despite initiation of targeted therapy, the patient took discharge against medical advice, preventing further outcome assessment. This case highlights the challenges of diagnosing melioidosis, particularly in rural settings where it mimics other tropical infections. Early suspicion, appropriate microbiological workup, and prompt initiation of effective antimicrobial therapy are crucial for improved outcomes. Greater clinician awareness and expanded diagnostic capacity are needed to prevent missed diagnoses and reduce mortality in endemic regions.
Clinical Manifestations of Vernal Keratoconjunctivitis and Its Effects on School Attendance and Access to Medical Care in School Children of Western Uttar Pradesh
(Medsci Publications, 2024-10) Yadav, M; Mehrotra, N; Tripathi, S; Arora, P.
Introduction: Vernal Keratoconjunctivitis (VKC) is a chronic ocular condition affecting school-age children, particularly in hot, allergen-rich regions. It presents with symptoms such as intense itching, tearing, foreign body sensation, and sticky discharge, causing discomfort and management challenges in resource-limited settings. VKC impacts public health significantly due to its high prevalence and effect on academic performance and school attendance. Method: This cross-sectional study included 1521 school children aged 6 to 16 years in Western Uttar Pradesh. Comprehensive eye examinations were conducted, and VKC was diagnosed based on conjunctival and limbal papillae. A structured questionnaire collected data on socio-demographic factors, medical care access, and VKC's impact on daily life and school attendance. Descriptive statistics and Pearson chi-square tests were used for analysis. Result: Of the participants, 242 (15.9%) had VKC, with a higher prevalence among boys (56.2%). Most cases were mild (66%), with 34% severe. Symptoms included itching, stinging, tearing, photophobia, and discharge. Severe VKC resulted in higher rates of constant eye rubbing and tear production. School absenteeism was significantly higher in severe cases (78%) compared to mild cases (47%) (P<0.001). Severe VKC also led to more frequent medical consultations (52% vs. 22%, P=0.01). Conclusion: VKC significantly affects school attendance and medical care utilization among children in Western Uttar Pradesh. Improved management practices, better access to medical care, and enhanced support systems are essential for affected children and families.
Clinico-Epidemiological Study of Cutaneous Superficial Fungal Infections: Multicentre Descriptive Study
(Medsci Publications, 2025-03) Rather, PA; Tilwani, MR
Background: Cutaneous superficial fungal infections or dermatophytosis, have emerged as common dermatoses with increasing incidence, prevalence, and relapse rate. This study aimed to provide a comprehensive clinico-epidemiological profile of dermatophytosis in our population. Material & Methods: This cross-sectional, descriptive study was conducted in two teaching hospitals in north India. A total of 1,520 patients with clinically diagnosed dermatophytosis were enrolled. Demographic data, clinical presentation, risk factors, and comorbidities were recorded. Scrapings from skin, nails, and hair were collected for direct microscopic examination. Patients were prescribed appropriate antifungal therapy and appropriately followed up. Results: Tinea corporis was the most common clinical presentation (41.0%), followed by tinea cruris (31.0%) and tinea pedis (15.0%). Poor hygiene practices (31.0%), occlusive clothing (26.0%), and obesity (21.0%) were the most common risk factors. KOH mount had positivity rate of 80.0%. Complete resolution of lesions was achieved in 70.0% of patients, while recurrence rate within 12 weeks was 18.0%. Conclusion: This study provides valuable insights into the clinico-epidemiological profile of dermatophytosis in India. High prevalence and recurrence rates highlight the need for targeted prevention strategies and optimized treatment approaches. Further research is warranted to explore emerging trends and develop novel diagnostic and therapeutic strategies.
Clinico-Epidemiological Study of Scalp Dermatosis at Tertiary Care Centre in Central India
(Medsci Publications, 2025-06) Khan, R; Rathoriya, SG; Singhal, R; Sharma, S; Dhurve, AK
Background: The human scalp, with its high follicular density and significant sebum production, is uniquely susceptible to a various dermatological condition. Common scalp disorders, including seborrheic dermatitis, psoriasis, tinea capitis, scalp folliculitis, and allergic contact dermatitis, each present with overlapping symptoms such as pruritus, scaling, inflammation, and hair loss, complicating accurate diagnosis and treatment. While global awareness of the impact on personal appearance and social interactions is increasing, research specifically focusing on scalp dermatoses in India remains limited. Methods and materials: This hospital-based observational study, conducted over one year (from September 2023- august 2024) with Institutional Ethics approval, aimed to investigate scalp dermatoses in patients from the Dermatology Outpatient Department. All patients with scalp disorders were included after informed consent, with a detailed history and physical examination conducted. Results: The study included 152 patients with scalp dermatoses, consisting of 90 males (59.2%) and 62 females (40.8%). The most affected age group was 21-30 years, accounting for 51.31% of cases (n=78). The parietal region was the most frequently affected area, seen in 64.4% of cases. Among the various scalp dermatoses, autoimmune conditions were the most prevalent (28.93%), with alopecia areata being the most common (22.36%). Conclusion: Scalp dermatoses are common and can significantly impact physical and mental health, lowering self-esteem and quality of life. Conditions like dandruff and alopecia cause visible changes, leading to emotional distress. This study highlights the need for accurate diagnosis and treatment to address both the physical and psychological aspects of these conditions.
Cobb Syndrome, A Rare Disease – Case Report
(Medsci Publications, 2024-01) Soladhra, K; Verma, AK; Modh, J; Velani, D.
Cobb syndrome is a rare genetic disorder characterized by dermatomal pattern, with corresponding muscular, osseous, paraspinal, and/or spinal vascular lesions occurring at the same body somite (metamere). It is also known as spinal arteriovenous metameric syndrome (SAMS) and cutaneous meningospinal angiomatosis. We present a case of a 36 years old male presented to OPD with Complain of progressive weakness of Right upper limb for 5 years. On examination, Patient had large cutaneous port wine stain on the right side of the chest, nape of neck, and along the whole right upper limb in a dermatomal distribution with ulnar claw hand wasting of thenar muscles on right side. MRI cervical spine with contrast showed aggressive vertebral hemangioma involving anterior and posterior arch of C1 vertebra, vertebral body of C2 to C5, right half of vertebral body of C2 and C6 and right pedicle of C2 to C5 vertebra. Abnormal thickened and T2WI /STIR hyperintense skin and subcutaneous tissue involving right half of scalp and right half of neck which showing post contrast enhancement, possibility of subcutaneous hemangioma. Cobb syndrome was diagnosed based on the dermatomal distribution of the cutaneous vascular lesions and the corresponding vertebral, epidural, and paraspinal vascular lesions occurring at the same metamere. Treatment decision is guided by the patient’s symptoms and imaging features.
A Community Based Cross Sectional Study on Skin Disorders in Children Attending Integrated Child Development Scheme (ICDS) Centres in Tirunelveli (Urban), Tamil Nadu, India
(Medsci Publications, 2025-03) Abirami, S; Savada, Moorthi, SM; Govardhanan, VM; Palanivel, N
Background & objectives: Survey of pre-school and school children is a useful yardstick for identification of infective dermatoses as early as possible and to prevent the upcoming epidemics among the community. Except for few hospital-based studies, there are no studies among pre-school children in community level including ICDS centres. Hence, we took an initiative for this study which has its implications on various health care policies and services catered to the children. Methodology: A cross-sectional study was conducted among children of 3 to 5 years of age attending ICDS centres in urban Tirunelveli over a period of 2 months (2018). A sample size of 405 was chosen from 23 centres by stratified random sampling. The screening and clinical diagnosis of dermatoses was made. Descriptive statistical analysis was followed. Results: A total of 405 children (204 boys & 201 girls) were screened and the prevalence of skin disorders was 8.14% (n=33). Infectious, non-infectious and nutritional deficiency disorders accounted for 2.46%, 4.7% and 0.98% respectively. Among infections and non-infectious dermatoses, pityriasis versicolor and papular urticaria was the commonest respectively. Interpretation& conclusions: Infectious dermatoses were in low numbers compared to non-infectious dermatoses reflecting the non-contagious environment. Absence of nutritional dermatoses and good hygiene reflect the well programmed health services and nutritional support provided to children in this part of Tamil Nadu.
Comparative Analysis of Infrapatellar and Suprapatellar Nailing Techniques for Tibial Shaft Fractures
(Medsci Publications, 2024-07) Nimavat, B; Majithiya, Y.
Introduction: Tibial shaft fractures pose a significant challenge in orthopaedic practice, often necessitating surgical intervention for optimal recovery. The selection of the entry point for intramedullary nailing, particularly between the suprapatellar and infrapatellar approaches, remains a debated aspect in fracture management. While both approaches aim to restore stability and function, their nuances influence outcomes and patient experiences. This study aims to comprehensively compare the suprapatellar and infrapatellar approaches, analyzing surgical techniques, complications, and functional outcomes to inform clinical decision-making. Methodology: A retrospective comparative analysis was conducted on patients undergoing intramedullary nailing for tibial shaft fractures, comparing outcomes between the suprapatellar and infrapatellar approaches. Data collection included patient demographics, fracture characteristics, intraoperative details, and postoperative outcomes. Statistical analysis was performed using appropriate tests, with a significance level set at p < 0.05. Result: Operative time was longer in the infrapatellar group (137.8 minutes) compared to the suprapatellar group (114.4 minutes). The mean radiation dose was higher in the infrapatellar group (74.3 cGY/cm2) and lower in the suprapatellar group (48.5 cGY/cm2). Postoperative outcomes showed a mean Lysholm score of 74 in the infrapatellar group and 90 in the suprapatellar group. one case of infection and one case of malunion were reported in the infrapatellar group, while the suprapatellar group had one infection case but no instances of non-union or malunion. Conclusion: This study provides valuable insights into the surgical and clinical outcomes of the suprapatellar and infrapatellar approaches for tibial shaft fractures. While both techniques offer viable options, the suprapatellar approach may offer advantages in terms of operative efficiency and functional recovery.
Comparative Analysis of Vaccination Status in Enteric Fever: Correlating Clinical and Laboratory Parameters
(Medsci Publications, 2024-01) Patel, N; Sasani, K; Shah, S.
Introduction: The emergence of resistant haplotypes of Salmonella makes control via vaccination an urgent priority. This study was conducted to evaluate the clinical and investigative profile of enteric fever cases admitted during study period at Nirmal hospital private limited, Surat and their typhoid immunization status to assess difference in presentation and clinic-investigation profile between immunized and unimmunized group. Methodology: This cross-sectional study conducted among children admitted with enteric fever. All the children were assessed for hepatitis vaccination status. Clinical and laboratory parameters were correlated with vaccination status. Results: Out of 101 study subjects, only 19 (18.81%) were immunized with any of the typhoid vaccine. Signs-symptoms and complications were not associated with immunization status (p > 0.05). Lower hemoglobin level and higher WBC count were associated with immunization status (p <0.05). The mean difference in Absolute Eosinophil Count was found statistically insignificant. (p 0.109) between two groups. Conclusion: The enteric fever is more common in school going age group of 5-14 years of age. Vaccination against typhoid provides protection against infection with S. Typhi. Vaccination can also help to reduce anemia during episode of enteric fever.
Comparative Evaluation of Midazolam and Ketamine with Midazolam Alone as Oral Premedication in Children
(Medsci Publications, 2022-01) Modi, Shreya; Patel, Subhash
Introduction: The main aims of preanesthetic medication in children are to reduce anxiety associated with the unfamiliar environment, facilitate the separation of the child from their parent and allow smooth induction of anesthesia. Both oral midazolam and oral ketamine fulfil many of these characteristics and are useful. Method: As 48 patients of ASA grade 1 and 2, aged between 2-10 years undergoing elective surgery were allocated to one of two study groups using random numbers: Group 1 received midazolam 0.5mg/kg and group 2 received midazolam 0.25 mg/kg with ketamine 3 mg/kg. The medications were prepared and mixed with 25% dextrose up to a maximum volume of 0.3 ml/kg. Result: Uniform and acceptable sedation scores were seen in both the groups, without any serious side effects. However, the combination offered significantly more children in an awake, calm and quiet state, who were easily separated from their parents. The induction scores, Recovery room characteristics and time to achieve satisfactory Aldrete score were also comparable between the two groups. Conclusion: Oral midazolam alone and a combination of midazolam with ketamine provide equally effective anxiolysis and separation characteristics. However, the combination provided more Benefits.
A Comparative Study Between Collagen Sheet Dressing and Conventional Paraffin Gauze Dressing to Donor Site in Patients Undergoing Split Skin Grafting
(Medsci Publications, 2025-03) Rajavarman, B; Manigandan, R; Sangeethapriya, AS; Somasundaram, UR
Introduction: Split skin grafting is a common procedure that causes partial thickness injury, typically treated with paraffin-soaked gauze. Re-epithelialization occurs in two weeks, but complications like pain, infection, and delayed healing can arise. This study aimed to compare collagen sheet dressing with conventional gauze dressing in reducing pain, promoting healing, and preventing infection in donor sites. Material and Methods: A prospective comparative study was conducted at a tertiary care hospital from December 2021 to January 2024. Fifty patients undergoing split skin graft surgery were assigned to either Group A (collagen sheet) or Group B (paraffin gauze). Outcomes such as pain, re-epithelialization, and infection were compared using descriptive statistics, chi-square, Fischer’s exact, and Student’s t-tests. P<0.05 was considered significant. Results: The mean age of Group A and Group B was 53.92 and 56.6 years, respectively. Pain scores were significantly lower in the collagen group (P<0.05). Epithelialization on day 10 was higher in the collagen group (85.2±5.09) compared to the conventional group (68.4±8). One patient in the conventional group had an infection, whereas none were observed in the collagen group. Conclusion: Collagen sheet dressing in split skin grafting donor sites results in reduced pain, faster epithelialization, and lower infection rates.
A Comparative Study Between Intravenous Magnesium Sulphate and Intravenous Isoxsuprine for Arrest of Preterm Labour
(Medsci Publications, 2024-01) Jeswani, R; Patil, Y; Lalwani, S; Dudve, M.
Introduction: Wide use of medical management of preterm labour has been obstructed due to low success rate of arrest of labour. This is aggravated by higher incidence of serious side effect of the available tocolytic agents, especially beta-mimetic tocolytics. With this background, the present study was carried out to compare the efficacy and maternal side effect of magnesium sulphate and Isoxsuprine in the arrest of preterm labour Methodology: This was a comparative prospective interventional study conducted among pregnant women coming to department of obstetrics and gynaecology with 28 to 37 weeks of gestation. Patients were divided in to two groups - Group 1 receiving Isoxsuprine and Group 2 receiving Magnesium Sulphate. Base line profile and outcome were compared between the two study groups. Results: Magnesium sulphate was more effective in arresting labour compared to Isoxsuprine (p<0.05). Tachycardia and hypotension were observed more frequently in group1 (Isoxsuprine) compared to group 2 (MgSO4). In cases having <1 cm dilatation and or less than 25% effacement MgSO4 was significantly more effective that Isoxsuprine for tocolysis. Conclusion: Magnesium sulphate is a more effective tocolytic agent than Isoxsuprine. Magnesium sulphate produce lesser maternal and foetal side effects like hypotension, palpitation, tachycardia as compared to Isoxsuprine.
Comparative Study of Efficacy and Safety of Rocuronium Bromide with Suxamethonium Chloride for Tracheal Intubation
(Medsci Publications, 2025-06) Wagh, A; Karande, A; Page, S; Dabade, V
Background: Tracheal intubation is a cornerstone of modern anesthetic practice, with neuromuscular blocking agents playing a critical role. Among these agents, Suxamethonium chloride is widely used for its quick onset and brief duration. However, its associated side effects have prompted the search for alternatives like Rocuronium Bromide, a non-depolarizing agent known for its rapid onset, intermediate duration, and minimal adverse effects. The study aims to compare the effectiveness and safety of Suxamethonium chloride and Rocuronium Bromide. It evaluates their onset times, intubating conditions, duration of action, hemodynamic effects, and adverse reactions. Materials and Methods: A randomized trial was conducted with 110 patients divided into two groups. Group A received Suxamethonium (1.5 mg/kg IV), and Group B was administered Rocuronium (0.9 mg/kg IV). Observations were made on intubation quality, onset timing, and hemodynamic changes. Results: Group A exhibited faster onset and superior intubating conditions (100% excellent scores) compared to Group B (87.3% excellent scores). However, Rocuronium demonstrated longer duration of action, hemodynamic stability, with significantly lower postoperative heart rate and blood pressure fluctuations. Additionally, Group B had no reported adverse effects, while Group A experienced 12.7% postoperative myalgia. Conclusion: Rocuronium represents a safer alternative for tracheal intubation, with enhanced hemodynamic stability and fewer side effects, despite slightly less favorable intubating conditions than Suxamethonium.

Browse

Browsing National Journal of Medical Research by Title

Results Per Page

Sort Options