Browsing by Author "Sanong Chomko"
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Item Effects of Leaf Extracts from Piper sarmentosum Roxb., Lagerstroemia speciosa (L.) Per. and Centella asiatica (L.) Urban. on Blood Glucose Level, Chemistry of Urine, Histology of Small Intestine and Hematological Values in Diabetic Rats(Journal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม, 2010-02-15) Thippawan Pila; Chusri Talubmook; Sanong ChomkoThis research was aimed to investigate the effects of ethanolic leaf extracts from Piper sarmentosum Roxb., Lagerstroemia spesiosa (L.) Per. and Centella asiatica (L.) Urban. on blood glucose levels, urine volume and chemical properties, histology of small intestine and hematological values in diabetic rats. The experiments were conducted by daily and oral feeding the leaf extracts from these three plants at the dose of 250 mg/kg to streptozotocin-induced diabetic rats for eight weeks. The results showed that all the extracts used could reduce blood glucose levels and increase in the body weight gain. The extract from Lagerstroemia spesiosa (L.) Per leaves reduced blood glucose levels (58.06±3.49%) greater than the extract from Centella asiatica (L.) Urban. leaves (23.03±9.09%). The extract from Piper sarmentosum Roxb. leaves reduced blood glucose levels in early 3 weeks of experiment. The feature of small intestine tissues from Piper sarmentosum Roxb., Lagerstroemia spesiosa (L.) Per. and Centella asiatica (L.) Urban. were not different from normal and glibenclamide treated. Moreover, all of extracts exerted any alteration of % hematocrit, g % hemoglobin, red blood cell and white blood cell count were not different but significantly higher (p \< 0.05) than diabetic group. Urine volume and chemical properties of all extract treated rats were not different from control and glibenclamide treatments. These findings indicated the leaf extracts from Piper sarmentosum Roxb., Lagerstroemia spesiosa (L.) Per. and Centella asiatica (L.) Urban. can be used for lowering blood glucose level but had no effect on volume and chemical properties of urine, histology of small intestine and hematological values in diabetic rats.Item Effects of Powder and Extract from Morus alba Linn. Leaves on Blood Glucose Level, Hematological Values and Chemical Properties of Urine in Diabetic Rats(Journal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม, 2010-03-02) Chusri Talubmook; Kanya Madcharoen; Sudarat Tochalee; Sanong ChomkoThe effects of powder and extract from mulberry (Morus alba Linn.) leaves on the blood glucose levels, packed cell volume, blood cell count, and also volume and chemical properties of urine in streptozotocin-induced diabetic rats were compared. The experiments were conducted by daily and oral administration of the powder or extract from mulberry (Morus alba Linn.) leaves at a dosage of 250 mg/kg body weight to the diabetic rats for 8 weeks. The results showed that both the powder and extract from mulberry leaves could lower the blood glucose level in the diabetic rats (14.23±6.13 and 25.77±4.53 % respectively). Although no significant differences were found, the extract tended to lower the blood glucose level greater than the powder. In addition, the powder and extract from mulberry leaves had no effects on packed cell volume, blood cell count, and also volume and chemical properties of urine in the diabetic rats compared to controls. These findings indicated an antihyperglycemic activity of mulberry leaves and may be further developed to use as diet supplement.Item Effects of Powder and Extract from Piper sarmentosum Roxb. Leaves and Tinospora crispa Miers. ex Hook. F \& Thoms. Stems on Blood Glucose Level Hematological Values in Diabetic Rats(Journal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม, 2010-03-02) Areeya Suchantabud; Chusri Talubmook; Sanong ChomkoThe extract and powder from Piper sarmentosum Roxb leaves and from Tinospora crispa Miers. ex Hook. F \& Thoms. stems at the dose of 250 mg/kg were daily and orally given to streptozotocin-induced diabetic rats for eight weeks. The blood glucose levels, packed cell volume, blood cell count, and also hemoglobin concentration in diabetic rats were investigated. The results showed the hypoglycemic activities of P. sarmentosum leaves and T. crispa stems in diabetic rats. However, the powder from P. sarmentosum leaves lowered the blood glucose level greater than the others (p \< 0.05). The extract and powder from P. sarmentosum leaves and T. crispa stems produced no significant differences on packed cell volume, red and white blood cell counts, and also hemoglobin concentration in diabetic rats. The extract and powder from P. sarmentosum leaves and powder from T. crispa stems increased the number of red blood cells, but not the white blood cells, greater than those controls, diabetic controls and glibenclamide treatments (p \< 0.05). In contrast, the extract from T. crispa stems provided no alteration on the white blood cell count compared to controls. These findings indicated that the extract or powder from P. sarmentosum leaves and T. crispa stems can be used as antihyperglycemic agents. As their negative effects on the red and white blood cell count have been found, therefore, the long term hypoglycemic treatment using P. sarmentosum and T. crispa should be considered.