Effects of Powder and Extract from Piper sarmentosum Roxb. Leaves and Tinospora crispa Miers. ex Hook. F \& Thoms. Stems on Blood Glucose Level Hematological Values in Diabetic Rats
No Thumbnail Available
Date
2010-03-02
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม
Abstract
The extract and powder from Piper sarmentosum Roxb leaves and from Tinospora crispa Miers. ex Hook. F \& Thoms. stems at the dose of 250 mg/kg were daily and orally given to streptozotocin-induced diabetic rats for eight weeks. The blood glucose levels, packed cell volume, blood cell count, and also hemoglobin concentration in diabetic rats were investigated. The results showed the hypoglycemic activities of P. sarmentosum leaves and T. crispa stems in diabetic rats. However, the powder from P. sarmentosum leaves lowered the blood glucose level greater than the others (p \< 0.05). The extract and powder from P. sarmentosum leaves and T. crispa stems produced no significant differences on packed cell volume, red and white blood cell counts, and also hemoglobin concentration in diabetic rats. The extract and powder from P. sarmentosum leaves and powder from T. crispa stems increased the number of red blood cells, but not the white blood cells, greater than those controls, diabetic controls and glibenclamide treatments (p \< 0.05). In contrast, the extract from T. crispa stems provided no alteration on the white blood cell count compared to controls. These findings indicated that the extract or powder from P. sarmentosum leaves and T. crispa stems can be used as antihyperglycemic agents. As their negative effects on the red and white blood cell count have been found, therefore, the long term hypoglycemic treatment using P. sarmentosum and T. crispa should be considered.
Description
Keywords
Citation
Journal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม; Volume 27 Number 3 July-September 2008; 227-232