To Study the Effect of I.V. Dexmedetomidine by Two Different Means for Prevention of Pain Due to Propofol Injection

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dc.contributor.authorMahajan, Rajeshen_US
dc.contributor.authorMehta, Anjalien_US
dc.contributor.authorGupta, Vikasen_US
dc.date.accessioned2020-10-16T09:00:58Z
dc.date.available2020-10-16T09:00:58Z
dc.date.issued2020-10
dc.description.abstractBackground: The incidence of propofol injection pain during induction of general anaesthesia varies from28% to 85%. Purpose: To Study the Effect of I.V. Dexmedetomidine by Two Different Means for Preventionof Pain Due to Propofol Injection. Material and Methods: This prospective, randomized study we evaluatedthe effect of dexmedetomidine for reducing the incidence and severity of propofol injection pain by twodifferent approaches while evaluating the hemodynamic stability. 120 Patients undergoing elective surgicalprocedures were randomly divided into four groups; in group I and II with the aim of keeping the drug withinthe vein the forearm was squeezed with a tourniquet up to 70 mmHg for 20 sec; the patients were administered0.5µg/kg dexmedetomidine in Group 1 (n 30), 0.75µg/kg dexmedetomidine in Group 2 (n 30) for 5 min,followed by 15 ml of 1% propofol in all patients over 25 seconds to induce anaesthesia. In Group 3 and 4;0.5µg/kg and 0.75µg/kg dexmedetomidine was premixed with 15ml propofol respectively and administeredfor induction. Pain is graded on a 0– 6 scale. Results: Overall median propofol injection pain score reductionwas 65.75% with the maximum reduction of 80% seen in group 4 and minimum reduction of 50% in group1. There were statistically significant differences (p Â0.05) in both SBP and DBP and heart rate with themaximum decrease in all hemodynamic parameters in group 2 and 4. Conclusion: Pre-treatment withintravenous dexmedetomidine 0.75µg/kg, 5min prior to injection of long-chain triglyceride propofol is effectiveand safe in reducing the incidence and severity of pain due to propofol injection.en_US
dc.identifier.affiliationsDepartment of Anaesthesia and ICU, Govt. Medical College, Jammu, Jammu and Kashmir - Indiaen_US
dc.identifier.citationMahajan Rajesh, Mehta Anjali, Gupta Vikas. To Study the Effect of I.V. Dexmedetomidine by Two Different Means for Prevention of Pain Due to Propofol Injection. JK Science Journal of Medical Education and Research. 2020 Oct; 2020 Oct: 133-136en_US
dc.identifier.issn0972-1177
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211029
dc.languageenen_US
dc.publisherJK Scienceen_US
dc.relation.issuenumber3en_US
dc.relation.volume22en_US
dc.source.urihttps://www.jkscience.org/archives/volume223/7-%20Original%20Article.pdfen_US
dc.subjectPropofolen_US
dc.subjectInjection Painen_US
dc.subjectDexmedetomidineen_US
dc.titleTo Study the Effect of I.V. Dexmedetomidine by Two Different Means for Prevention of Pain Due to Propofol Injectionen_US
dc.typeJournal Articleen_US
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