Toxicological and clastogenic evaluation of pinocembrin and pinostrobin isolated from Boesenbergia pandurata in Wistar rats
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2011-01-24
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Thai Journal of Toxicology - วารสารพิษวิทยาไทย
Abstract
Pinocembrin (5, 7-dihydroxyflavanone) and pinostrobin (5-hydroxy-7-methoxy flavanone)are flavanones present in some natural products including the rhizome of Boesenbergia pandurata.Many reports showed their in vitro biological benefits without safety indication. The toxicity andmutagenicity of both flavanones in male Wistar rats were examined. There were no deaths observedfollowing a single oral administration of 500 mg/kg of both compounds. Body weight, vital organweights and blood biochemistry values of treated rats were not significantly different compared withthose of the control group. The mutagenicity of both flavanones using liver micronuclei in maleWistar rats was assessed. After feeding rats with 1-100 mg/kg for 7 days, the liver micronucleusformation and mitotic cells in hepatocytes were analyzed. Neither phytochemical affectedmicronucleus formation or mitotic index. Our results indicated that pinocembrin and pinostrobin arenon toxic and are not mutagenic to male Wistar rats within the 1-100 mg/kg interval.
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Thai Journal of Toxicology - วารสารพิษวิทยาไทย; Vol.25 No.1 January -June 2010; 29-40