Impact of C-reactive protein on disease risk and its relation to dietary factors.

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dc.contributor.authorNanri, Akikoen_US
dc.contributor.authorMoore, Malcolm Aen_US
dc.contributor.authorKono, Suminorien_US
dc.date.accessioned2009-05-27T17:41:08Z
dc.date.available2009-05-27T17:41:08Z
dc.date.issued2007-04-19en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention. 123 references.en_US
dc.description.abstractC-reactive protein (CRP) is one of the acute-phase proteins in inflammation and CRP serum concentrations are therefore of interest. Data for high-sensitivity CRP (hs-CRP) with a low detection limit of approximately 0.04 mg/L have become available over the past decade and research has shown a link between high concentrations of hs-CRP and obesity as well as smoking. Expanded adipose tissue is in fact known to secrete proinflammatory cytokines which enhance hepatic synthesis of CRP. Moderate alcohol consumption and high physical activity have been associated with low levels of hs-CRP, but the evidence in these cases is not conclusive. It has been suggested that hs-CRP is an independent marker of the risk of cardiovascular disease, but the predictive capacity remains controversial. However, many prospective studies have observed increased risk of type 2 diabetes mellitus associated with high concentrations of hs-CRP, independent of obesity and other cardiovascular risk factors. On the other hand, no measurable increase in the risk associated with high levels of hs-CRP was observed with multivariate adjustment in several studies. A number of authors have reported that high concentrations of hs-CRP are associated with increased risks of colorectal and other cancers, but the findings again are inconsistent. Diet and hs-CRP are also of increasing research interest. High intakes of carotenoids and vitamin C, but not of vitamin E, seem to decrease the level of circulating hs-CRP. In addition, high consumption of vegetables and fruit are associated with lower levels of circulating hs-CRP, perhaps by exerting anti-inflammatory effects. Both mechanistic and epidemiologic studies regarding dietary factors and low-grade inflammation are necessary to add to our knowledge of dietary influence on chronic disease development.en_US
dc.description.affiliationDepartment of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. nnrakiko@phealth.med.kyushu-u.ac.jpen_US
dc.identifier.citationNanri A, Moore MA, Kono S. Impact of C-reactive protein on disease risk and its relation to dietary factors. Asian Pacific Journal of Cancer Prevention. 2007 Apr-Jun; 8(2): 167-77en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37672
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdipose Tissue --physiologyen_US
dc.subject.meshAntioxidants --therapeutic useen_US
dc.subject.meshAtherosclerosis --blooden_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshC-Reactive Protein --analysisen_US
dc.subject.meshColorectal Neoplasms --epidemiologyen_US
dc.subject.meshDieten_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation --blooden_US
dc.subject.meshSensitivity and Specificityen_US
dc.titleImpact of C-reactive protein on disease risk and its relation to dietary factors.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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