Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina.
dc.contributor.author | Singh, R K | en_US |
dc.contributor.author | Gambhir, S S | en_US |
dc.date.accessioned | 2009-05-28T13:17:17Z | |
dc.date.available | 2009-05-28T13:17:17Z | |
dc.date.issued | 1992-12-01 | en_US |
dc.description.abstract | Three agents known to induce release of mast cell constituents, viz. polymyxin, compound 48/80 and polysorbate-80, were evaluated for effect on perfused blood vessels of R. tigrina and B. melanostictus. The mast cell degranulators caused vasoconstriction in frog and toad, except that for P-80 whose responses in toad were equivocal. Toads showed a general low responsiveness in comparison to frogs. Pharmacologic intervention with pheniramine, metergoline, hydergine, atropine and mecamylamine, respectively ruled out role of histamine, 5-HT, catecholamine or acetylcholine or even autonomic mechanisms in the above phenomena. The observations are suggestive of phylogenetic differences in biochemical profile of mast cells in amphibian species. | en_US |
dc.description.affiliation | Department of Pharmacology, Banaras Hindu University, India. | en_US |
dc.identifier.citation | Singh RK, Gambhir SS. Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina. Indian Journal of Experimental Biology. 1992 Dec; 30(12): 1176-80 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/59211 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.asp | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bufonidae | en_US |
dc.subject.mesh | Histamine --pharmacology | en_US |
dc.subject.mesh | Histamine Antagonists | en_US |
dc.subject.mesh | Mast Cells --drug effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular --drug effects | en_US |
dc.subject.mesh | Perfusion | en_US |
dc.subject.mesh | Polymyxins --pharmacology | en_US |
dc.subject.mesh | Polysorbates --pharmacology | en_US |
dc.subject.mesh | Ranidae | en_US |
dc.subject.mesh | Serotonin --pharmacology | en_US |
dc.subject.mesh | Tachyphylaxis | en_US |
dc.subject.mesh | Vasoconstriction --drug effects | en_US |
dc.subject.mesh | p-Methoxy-N-methylphenethylamine --pharmacology | en_US |
dc.title | Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina. | en_US |
dc.type | In Vitro | en_US |
dc.type | Journal Article | en_US |
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