Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina.

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dc.contributor.authorSingh, R Ken_US
dc.contributor.authorGambhir, S Sen_US
dc.date.accessioned2009-05-28T13:17:17Z
dc.date.available2009-05-28T13:17:17Z
dc.date.issued1992-12-01en_US
dc.description.abstractThree agents known to induce release of mast cell constituents, viz. polymyxin, compound 48/80 and polysorbate-80, were evaluated for effect on perfused blood vessels of R. tigrina and B. melanostictus. The mast cell degranulators caused vasoconstriction in frog and toad, except that for P-80 whose responses in toad were equivocal. Toads showed a general low responsiveness in comparison to frogs. Pharmacologic intervention with pheniramine, metergoline, hydergine, atropine and mecamylamine, respectively ruled out role of histamine, 5-HT, catecholamine or acetylcholine or even autonomic mechanisms in the above phenomena. The observations are suggestive of phylogenetic differences in biochemical profile of mast cells in amphibian species.en_US
dc.description.affiliationDepartment of Pharmacology, Banaras Hindu University, India.en_US
dc.identifier.citationSingh RK, Gambhir SS. Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina. Indian Journal of Experimental Biology. 1992 Dec; 30(12): 1176-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59211
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBufonidaeen_US
dc.subject.meshHistamine --pharmacologyen_US
dc.subject.meshHistamine Antagonistsen_US
dc.subject.meshMast Cells --drug effectsen_US
dc.subject.meshMuscle, Smooth, Vascular --drug effectsen_US
dc.subject.meshPerfusionen_US
dc.subject.meshPolymyxins --pharmacologyen_US
dc.subject.meshPolysorbates --pharmacologyen_US
dc.subject.meshRanidaeen_US
dc.subject.meshSerotonin --pharmacologyen_US
dc.subject.meshTachyphylaxisen_US
dc.subject.meshVasoconstriction --drug effectsen_US
dc.subject.meshp-Methoxy-N-methylphenethylamine --pharmacologyen_US
dc.titleComparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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