Protective effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas.

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dc.contributor.authorVijayaraghavan, Ren_US
dc.contributor.authorGautam, Anshooen_US
dc.contributor.authorKumar, Omen_US
dc.contributor.authorPant, S Cen_US
dc.contributor.authorSharma, Manojen_US
dc.contributor.authorSingh, Seemaen_US
dc.contributor.authorKumar, H T Satishen_US
dc.contributor.authorSingh, Anand Kumaren_US
dc.contributor.authorNivsarkar, Manishaen_US
dc.contributor.authorKaushik, M Pen_US
dc.contributor.authorSawhney, R Cen_US
dc.contributor.authorChaurasia, O Pen_US
dc.contributor.authorPrasad, G B K Sen_US
dc.date.accessioned2009-05-28T14:26:09Z
dc.date.available2009-05-28T14:26:09Z
dc.date.issued2006-10-30en_US
dc.description.abstractEthanolic extract of H. rhamnoides L. leaf (HL-EOH), water and ethanolic extract of H. rhamnoides fruit (HF-W and HF-EOH), and H. rhamnoides flavone from fruit (HR-flavone) were evaluated against percutaneously administered sulphur mustard (SM), a chemical warfare agent. The animals administered with SM (9.7, 19.3 and 38.7 mg/kg) died at various days depending upon the dose and there was a significant reduction in the body weight. The H. rhamnoides extracts (1 g/kg; 3 doses; po) significantly protected the lethality, with a protective index of 2.4, 1.7, 1.7 and 2.2 for HL-EOH, HF-W, HF-EOH and HR-flavone respectively. Reduced glutathione (GSH) and oxidized glutalthione (GSSG) levels were reduced, and malondialdehyde (MDA) was elevated after percutaneous administration of SM. Oral administration of HL-EOH and HR-flavone significantly protected the body weight loss. Recovery in the levels of GSH, GSSG and MDA were also observed following oral administration of HL-EOH and HR-flavone. All the extracts were non-toxic and the LD50 was more than 5 g/kg. The present study shows that percutaneous administration of SM induces oxidative stress and ethanolic extract of leaf of H. rhamnoides and H. rhamnoides flavone from fruit can significantly protect it.en_US
dc.description.affiliationDefence Research and Development Establishment, Gwalior 474 002, India. vijayjai@sancharnet.inen_US
dc.identifier.citationVijayaraghavan R, Gautam A, Kumar O, Pant SC, Sharma M, Singh S, Kumar HT, Singh AK, Nivsarkar M, Kaushik MP, Sawhney RC, Chaurasia OP, Prasad GB. Protective effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas. Indian Journal of Experimental Biology. 2006 Oct; 44(10): 821-31en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60705
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6623/1/IJEB%2044%2810%29%20821-831.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --isolation & purificationen_US
dc.subject.meshChemical Warfare Agents --toxicityen_US
dc.subject.meshEthanolen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlavones --isolation & purificationen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshGlutathione Disulfide --metabolismen_US
dc.subject.meshHippophaeen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMalondialdehyde --metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMustard Gas --toxicityen_US
dc.subject.meshOxidative Stress --drug effectsen_US
dc.subject.meshPlant Extracts --isolation & purificationen_US
dc.subject.meshSkin --drug effectsen_US
dc.subject.meshSpleen --drug effectsen_US
dc.subject.meshWateren_US
dc.titleProtective effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas.en_US
dc.typeJournal Articleen_US
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