Correlation of Adenosine Deaminase Activity with Glycated Hemoglobin Levels in Type II Diabetes Mellitus

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dc.contributor.authorSiddiqui, Azraen_US
dc.contributor.authorSiddiqui, Aqeelah Mohammeden_US
dc.contributor.authorSiddiqui, Mohammed Abdul Mujeeben_US
dc.contributor.authorDevi, M. Umaen_US
dc.date.accessioned2025-05-09T11:04:41Z
dc.date.available2025-05-09T11:04:41Z
dc.date.issued2024-06
dc.description.abstractIntroduction: Diabetes mellitus is not a single disease entity but rather a group of metabolic disorders characterized by hyperglycemia which results from defects in insulin secretion, insulin action or most commonly both. The chronic hyperglycemia and attendant metabolic dysregulation may be associated with secondary damage in multiple organ systems, especially the kidneys, eyes, nerves and blood vessels. Materials and methods: The present study includes 90 subjects, of which 60 were cases of type 2 DM from Department of Endocrinology, Osmania General Hospital. Investigations were performed at the Department of Biochemistry, Osmania Medical College/ Osmania General Hospital; Hyderabad and results were analyzed. Results: A total of 90 patients were recruited for the study which included 30 Type II Diabetes mellitus patients with glycated hemoglobin ? 7 %, 30 Type II Diabetes mellitus with glycated hemoglobin < 7% and 30 healthy individuals as controls. The following parameters were analyzed.1. Fasting plasma glucose, 2.Glycated hemoglobin (HbA1C), 3.Serum Adenosine deaminase, 4. Serum uric acid The data was analyzed using Graph Pad Prism software version 7.0. Descriptive results are expressed as mean and SD of various parameters in different groups. Conclusions: There is clear cut elevation of serum ADA in Type 2 Diabetes mellitus. But due to short half life and diurnal variations of ADA, to establish ADA as a routine diagnostic and prognostic marker in the laboratory, substantial number of samples have to be analyzed in larger and more elaborate studies.en_US
dc.identifier.affiliationsAssistant Professor, Department of Biochemistry, Arundathi Institute of Medical Sciences, Dundigal, Telangana, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Biochemistry, Dr. Patnam Mahender Reddy Institute of Medical Sciences, Chevella, Telangana, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Forensic Medicine, Deccan College of Medical Sciences, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsProfessor and Head of the Department of Biochemistry, Bhaskar Medical College, Yenkapally, Moinabad, Telangana, India.en_US
dc.identifier.citationSiddiqui Azra, Siddiqui Aqeelah Mohammed, Siddiqui Mohammed Abdul Mujeeb, Devi M. Uma . Correlation of Adenosine Deaminase Activity with Glycated Hemoglobin Levels in Type II Diabetes Mellitus. International Journal of Contemporary Medical Research. 2024 Jun; 11(6): 1-5en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246171
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber6en_US
dc.relation.volume11en_US
dc.source.urihttps://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_3739.pdfen_US
dc.subjectFasting blood glucoseen_US
dc.subjectHyperglycemiaen_US
dc.subjectInsulinen_US
dc.subjectMetabolic dysregulationen_US
dc.subjectUric acid.en_US
dc.titleCorrelation of Adenosine Deaminase Activity with Glycated Hemoglobin Levels in Type II Diabetes Mellitusen_US
dc.typeJournal Articleen_US
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